肾上腺髓质素和内皮素在鲍曼不动杆菌医院获得性肺炎患者血浆中含量的变化

Acquired Pneumonia due to Acinetobacter Baumannii

目的探讨血清肾上腺髓质素及内皮素在鲍曼不动杆菌(AB)医院获得性肺炎患者血浆中含量的变化及临床意义。方法采用ELISA法测定30例AB医院获得性肺炎患者(研究组)和60例健康体检者(对照组)血清中肾上腺髓质素(ADM)的含量。结果研究组血浆ADM为(65.4±18.7)ng/ml,对照组为(32.0±8.7)ng/ml,差异有统计学意义(t=8.85,P<0.01)。研究组血浆ET-1为(105.6±16.6)ng/ml,对照组为(79.7±5.6)ng/ml,差异有统计学意义(t=6.73,P<0.01)。结论 ET及ADM在鲍曼不动杆菌医院获得性肺炎患者血浆中有明显升高,ADM可能在气道保护及抗感染方面起重要作用。

Objective To investigate the plasma level of adrenomedullin （ADM） and endothelin （ET） in patients with pneumonia due to Acinetobacter Baumannii（AB） and its clinical significance. Methods Thirty patients with AB pneumonia （study group） and 60 healthy subjects （control group） were tested for the serum level of ADM and ET by ELISA. Resuits The plasma level of ADM and ET in the study group were （65.4±18.7 ） ng/ml and （ 105.6±16.6） ng/ml respectively, while （32.0±8.7） ng/ml and （79.7±5.6） ng/ml in control group. Significant difference was found between the two groups. Conclusion The plasma level of ADM and ET increased significantly in patients with AB pneumonia. ADM probably plays an important role in airway protection and anti -inflammatory actions.