不同时间给药对非杓型高血压的影响

Different time amlodipine non-dipper hypertensive patients blood pressure

目的探讨不同时间服用氨氯地平对非杓型高血压患者血压昼夜节律的影响。方法经动态血压监测,选取非杓型高血压患者84例,随机分为两组:晨起服药组(n=42)和睡前服药组(n=42),分别于7:00～9:00和20:00～22:00服用氨氯地平5mg,连续治疗12周。给药前后分别进行动态血压监测,观察晨起服药组和睡前服药对非杓型高血压患者昼夜血压节律的影响。结果晨起服药组与睡前服药组在治疗后24h平均收缩压及舒张压均明显降低(P<0.05),与晨起服药组相比睡前服药组夜间收缩压和舒张压明显下降(P<0.05),睡前服药组对非杓型高血压的血压模式明显改善,两组有效率分别为16.7%和47.6%(P<0.01)。结论对非杓型高血压患者采取睡前服用氨氯地平不但可以有效降低血压,还可以改善异常的血压昼夜节律,从而更好地保护靶器官。

Objective To explore the different time amlodipine non-dipper hypertensive patients with circadian rhythm of blood.Methods By ambulatory blood pressure monitoring,select the 84 cases of non-dipper hypertensive patients were randomly divided into two groups：early morning medication group（n=42） and bedtime medication group（n=42）,respectively,7：00~9：00 and 20：00~22：00 amlodipine 5 mg,12 weeks of continuous treatment.Ambulatory blood pressure monitoring before and after administration were observed early morning medication group and bedtime medication on the circadian rhythm in non-dipper hypertensive patients.Results Morning medication group and bedtime medication group 24 h after treatment the mean systolic and diastolic blood pressures were significantly lower（P0.05）,compared with early morning medication group before going to bed the treated group of night-time systolic and diastolic blood pressure decreased significantly（P0.05）,and bedtime blood pressure medication group of non-dipper hypertensive model significantly improved in both groups were 16.7% and 47.6%（P0.01）.Conclusion On the non-dipper hypertensive patients to take at bedtime amlodipine not only can effectively lower blood pressure,can also improve the abnormal circadian rhythm of blood,in order to better protect the target organ.