阿托伐他汀对颈动脉粥样硬化患者血浆同型半胱氨酸的影响

The effect of homocysteine of patients with carotid artery atherosclerosis

目的阿托伐他汀钙对老年颈动脉粥样硬化患者血浆同型半胱氨酸的(Hcy)作用。方法 96例老年颈动脉粥样硬化患者,随机分为3组,A组给予生活方式指导及服用拜阿司匹林,B组在A组基础上口服阿托伐他汀20 mg,C组在A组基础上口服阿托伐他汀40 mg,服药前及服药第4,6,8周分别测定斑块面积及血浆Hcy水平。结果 A组及B组斑块面积及Hcy水平较服药前无明显变化,C组斑块面积及Hcy水平于第6周降低,且第8周低于第6周。结论每日服用阿托伐他汀40 mg可降低颈动脉粥样硬化患者血浆Hcy水平,且此效应与其对颈动脉斑块面积的缩小作用时间保持一致。

Objective To observe the effects of atorvastatin calcium on plasma homocysteine of patients with carotid artery atherosclerosis.Methods Ninety-six patients with carotid artery atherosclerosis were divided into three groups.Patients of group A were given life style guidance and took 100 mg asprin per day as the base treatment.Patients of group B took extra 20 mg atorvastatin calcium orally on the basis of group A.In addition to the base treatment of group A,extra 40 mg atorvastatin calcium were taken orally by patients of group C.The area of carotid plaque and the level of homocysteine were detected before the treatment and on the 4th,6th,8th week after treatment respectively.Results No significant change was observed in group A and B before and after treatment in area of carotid plaque and the level of homocysteine,which decreased in group C from the 6th to 8th week,and more on the 8th week.Conclusion Taking 40 mg atorvastatin calcium everyday can help to decrease the homocysteine level of patients with carotid artery atherosclerosis,and this effect was parallel to the reduction of carotid plaque area.