川连抗癌的实验研究

An experimental study on the anti-tumor effect of Coptis chinensis Franch

目的通过对动物体内抗癌实验的观察研究,验证中药川连具有抑制和治疗肿瘤的生物学特性。方法选取80只昆明小鼠,于前肢皮下接种小鼠肉瘤细胞。将动物随机分为对照组和川连治疗组。治疗组每日给予川连汤剂稀释液(0.5 mg,瘤内注射,1次/d),连续10 d;对照组注射同体积生理盐水。结果连续观察70 d,治疗组小鼠存活率100%,对照组小鼠存活率为0%。结论中药川连具有抑制和治疗肿瘤作用,其抗肿瘤作用机制有待于进一步研究。

Objective To verify the anti-tumor effect of Coptis chinensis Franch through animal experiment. Method 80 Kunming mice were collected and subcutaneously vaccinated the mouse Sis0 ascitic ceils on the forelimbs of the animals. Then, the animals were randomly divided into control group and Coptis chinensis Franch treatment group. In the treatment group, the animals were injected with Coptis chinensis Franch （0.5 rag, intratumoral injection, Qd） for ten days, while the control animals were injected with identical volume of saline. Result After 70 days＇ observation, the survival rate of the treatment group was 100%, while that of the control group was 0%. Conclusion Coptis chinensis Franch has a strong anti-tumor effect, but the mechanism needs to be further studied.