2010年广州地区淋球菌耐药监测结果分析

Antibiotic resistance of Neisseria gonorrhoeae in Guangzhou: an analysis result

目的了解广州地区淋球菌对抗生素耐药性的变化及PPNG和TRNG的流行趋势。方法用琼脂稀释法测定头孢曲松、大观霉素、环丙沙星、阿奇霉素和四环素的最低抑菌浓度(MIC);用纸片碘量法检测β-内酰胺酶。结果 83株淋球菌检出PPNG 24株(28.9%)、TRNG 50株(60.2%)、环丙沙星耐药率高达98.8%,高度耐药株(MIC≥16 mg/L)43株(51.8%),而76株淋球菌中阿奇霉素耐药株11株(14.5%),均未出现对头孢曲松、大观霉素耐药的菌株,抗菌活性强。结论合理规范使用抗生素及动态监测淋球菌耐药性变迁是临床减少淋球菌耐药菌株出现的有效办法。

Objective To investigate the antibiotic resistance and the prevalence of PPNG and TRNG in Guangzhou. Method Minimum inhibitory concentrations （MICs） to ceftriaxone, spectiomycin, ciprofloxacin, azithromyc and tetracycline were determined using the agar dilution method, and β-lactamase by paper iodine quantitative method. Result 24 strains of Neisseria gonorrhoeae producing β-1actamase were detected in 83 strains, while 50 strains showed plasmid-mediated, high-level resistance to tetracycline （TRNG）. Resistance rate to ciprofloxacin was 98.8%. 43 strains were highly resistant （ MIC ≥ 16 rag/L） （51.8%）. Resistance rate to azithromyc was 14.5% （11/76）. No strains were found to be resistant to ceftriaxone and specitinomycin. Conclusion Using antibiotics rationally and the changes of resistance being monitored dynamically can effectively reduce the occurance of more resistant strains of Neisseriae gonorrhoeae.