肺动脉高压对结缔组织病患者左心室功能的影响

The Effect of Pulmonary Arterial Hypertension on Left Ventricular Function

目的探讨肺动脉高压(PAH)对结缔组织病(CTD)患者左心室功能的影响。方法选取结缔组织病患者34例,合并肺动脉高压者(CTD-PAH组)18例,未合并肺动脉高压者(CTD组)16例。选取正常对照组18例。采集左室侧壁(left ventriculer lateral wall,LVLW)二尖瓣环位点组织多普勒频谱(tissue Doppler imaging,TDI)和二尖瓣、主动脉瓣口血流脉冲多普勒频谱(pulse wave Doppler imaging,PW),测量左室等容舒张期(IRT)、等容收缩期(ICT)、射血期(ET)并计算左心室Tei指数(LVLWTei,PWTei)。结果 CTD-PAH组与CTD组、正常对照组比较,CTD-PAH组左心室Tei延长(P<0.05);左心室LVLWIRT、PWIRT延长(P<0.05);LVLFET、PWET缩短(P<0.05);CTD组与正常对照组间比较,差异均无显著性。结论肺动脉高压明显损伤结缔组织病患者左心室整体功能。

Objective To estimate the left ventricular （LV） global function in patients with pulmonary arterial hypertension （PAH） secondary to connective tissue disease （CTD）. Methods Echocardiographic images were prospectively acquired in 18 patients with PAH secondary to CTD, 16 patients with CTD group and 18 age- and gender-matched control group. Patients with intrinsic LV diseases were excluded. The Doppler sample volume was obstaind by TDI eehocardiography at left ventricnlar lateral wall sites of mitral annular, and by PW echocardiography at mitral valve and aortic valve. IRT, ICT, ET and Tei indexs were measured. Results LVLWTei, PWTei, LVLWIRT, PWIRT were increased in the PAH group than in CTD group and control group（P〈0.05 ） ; LVLWET and PWET were shorten; no There were no significant differences between CTD group and control group. Conclusion PAH impairs LV globe function in patients secondary to CTD.