摘要
Two rare earth substituted Keggin-type phosphomngstates containing 5-fluorouracil, K10C4H4FN2O2Y（PW11O39）2· 10H2O （FYPW） and Kg（C4H4FN2O2）2La（PWl1O39）2· 18H2O （FLaPW） were synthesized in aqueous solution, and the structures were characterized by Fourier transform infrared spectroscopy （FT-IR）, element analysis, inductively coupled plasma spectrometry （ICP）, X-ray powder diffraction （XRD） and 1H nuclear magnetic resonance （NMR）. Thermal analysis showed that the decomposition processes of the two compounds could be di- vided into three steps, the loss of crystal water, the decomposition of 5-fluorouracil unit and the decomposition of Keggin-type polyanions. The in vitro cytotoxicities against HEK 293, HeLa and HepG-2 cells were studied by methyl thiazolyl tetrazolium （MTT） assay. The results showed that FYPW and FLaPW had higher antitumor activities than 5-fluorouracil, C4H4FN2O2H2PW12O40.8H2O and rare earth substituted polyoxometalates KllLn（PW11O39）2@nH2O （Ln-Y, La）. It was concluded that introducing 5-fluorouracil and rare earth （Y or La） into its structure was a considerable way to enhance antitumor activities ofpolyoxometalates.
Two rare earth substituted Keggin-type phosphomngstates containing 5-fluorouracil, K10C4H4FN2O2Y（PW11O39）2· 10H2O （FYPW） and Kg（C4H4FN2O2）2La（PWl1O39）2· 18H2O （FLaPW） were synthesized in aqueous solution, and the structures were characterized by Fourier transform infrared spectroscopy （FT-IR）, element analysis, inductively coupled plasma spectrometry （ICP）, X-ray powder diffraction （XRD） and 1H nuclear magnetic resonance （NMR）. Thermal analysis showed that the decomposition processes of the two compounds could be di- vided into three steps, the loss of crystal water, the decomposition of 5-fluorouracil unit and the decomposition of Keggin-type polyanions. The in vitro cytotoxicities against HEK 293, HeLa and HepG-2 cells were studied by methyl thiazolyl tetrazolium （MTT） assay. The results showed that FYPW and FLaPW had higher antitumor activities than 5-fluorouracil, C4H4FN2O2H2PW12O40.8H2O and rare earth substituted polyoxometalates KllLn（PW11O39）2@nH2O （Ln-Y, La）. It was concluded that introducing 5-fluorouracil and rare earth （Y or La） into its structure was a considerable way to enhance antitumor activities ofpolyoxometalates.
基金
Project supported by Institution of Chemical Materials,China Academy of Engineering Physics
