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肠出血性大肠埃希菌O_(104)∶H_4血清型感染的流行概况和实验室检测方法 被引量：1

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摘要 德国爆发由大肠埃希菌O104∶H4血清型引发的溶血性尿毒综合征(hemolytic uremic syndrome,HUS)和出血性腹泻,主要涉及成年妇女。该菌结合了肠凝聚性大肠埃希菌(enteroaggregative Escherichia coli,EaggEC)和肠出血性大肠埃希菌(enterohe-morrhagic Escherichia coli,EHEC)的毒力性质和表型特征。以stx1、stx2等为目标基因,通过PCR技术检测志贺毒素,细菌分离培养结合生化反应、血清学分型提高筛检效率。该菌产ESBL复合物CTX-M15和β-内酰胺酶TEM-1,对青霉素类和头孢菌素类耐药,对碳青霉烯类敏感。该菌毒力增强可能与其对上皮细胞的黏附增强并促进志贺毒素全身性吸收有关。
作者 金姣 柯星 顾兵 潘世扬
机构地区 南京医科大学第一临床医学院医学检验系 南京医科大学第一附属医院医学检验科
出处 《临床检验杂志》 CAS CSCD 北大核心 2012年第5期361-363,共3页 Chinese Journal of Clinical Laboratory Science
基金 国家自然科学基金(81000754) 南京医科大学十二五教学研究课题(NY2222011048)
关键词 肠出血性大肠埃希菌 溶血性尿毒综合征 流行 实验室检测
分类号 R446.5 [医药卫生—诊断学]
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参考文献20

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二级参考文献32

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临床检验杂志
2012年 第5期

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