期刊文献+

儿童噬血细胞淋巴组织细胞增生症主要危险因素与预后关系研究进展 被引量:5

儿童噬血细胞淋巴组织细胞增生症主要危险因素与预后关系研究进展
原文传递
导出
摘要 1概述 噬血细胞淋巴组织细胞增生症(hemophagocytic1ymphohistiocytosis,HLH)是一组单核一巨噬细胞系统反应性增生而发生过度的炎症反应,造成多组织器官损害的综合征。目前,其病因及发病机制未完全阐明。促炎症反应的细胞因子不断生成,巨噬细胞和细胞毒性T淋巴细胞浸润多组织是其最显著特点[1]。
出处 《中国实用儿科杂志》 CSCD 北大核心 2012年第6期476-478,共3页 Chinese Journal of Practical Pediatrics
关键词 噬血细胞淋巴组织细胞增生症 预后 危险因素 hemophagocytic lymphohistiocytosis prognosis risk factors
  • 相关文献

参考文献27

  • 1Gholam C, Grigoriadou S, Gilmour KC, et al.Familial haemo- phagocytic lymphohistiocytosis: advances in the genetic basis, diagnosis and management [J].Clin Exp Immunol, 2011, 163 (3) :271-283.
  • 2Gurgey A, Gogus S, Ozyurek E, et al.Primary hemophagocytic lymphohistiocytosis in Turkish children[J].Pediatr Hematol On- col, 2003,20: 367-371.
  • 3Coo HW, Weon YC.A spectrum of neuroradiological findings in children with haemophagocytic lymphohistiocytosis [J].Pediatr Radiol,2007,37 : 1110-1117.
  • 4Home A, Trottestam H, Arico M, et al.Frequency and spectrum of central nervous system involvement in 193 children with hae- mophagocytic lymphohistiocytosis [ J ].Br J Haematol, 2008,140: 327-335.
  • 5Shinoda J, Murase S, Takenaka K, et al.Isolated central nervous system hemophagocytic lymphohistiocytosis: case report [ J ] .Neu- rosurgery,2005,56: E187-190.
  • 6Janka GE.Familial and acquired hemophagocytic lymphohistio- cytosis [ J ] .Eur J Pediatr, 2007,166 (2) : 95-109.
  • 7Sparber-Sauer M, Honig M, Schulz AS, et al.Patients with early relapse of primary hemophagocytic syndromes or with persistent CNS involvement may benefit from immediate hematopoietic stem cell transplantation [J].Bone Marrow Transplantation, 2009,44 : 333-338.
  • 8Imashuku S, Hyakuna N, Funabiki T, et al.Low natural killer ac- tivity and central nervous system disease as a high risk prognos- tic indicator in young patients with hemophagocytic lymphohis- tiocytosis [ J ] .Cancer, 2002,94: 3023-3031.
  • 9Trapani JA, Voskoboinik I.Infective, neoplastic, homeostatic.se- quelae of the loss of perforin function in humans [J].Adv Exp Med Biol, 2007,601 : 235-242.
  • 10Marc T, Marina C, Stephane B, et al.Hematopoietic stem cell transplantation in hemophagocytic lymphohistiocytosis: a sin- gle center report of 48 patients [J].Pediatfics, 2006, 117 (4) : 743-750.

二级参考文献37

  • 1段红梅,谢正德,申昆玲.EB病毒相关淋巴细胞增生性噬血综合征研究进展[J].临床儿科杂志,2005,23(7):425-429. 被引量:12
  • 2Kimura H, Ito Y, Suzuki R, et al. Measuring Epstein-Barr virus (EBV) load: the significance and application for each EBV-associated disease [J]. Rev Med Virol, 2005, 18: 305-319.
  • 3Janka GE. Familial and acquired hemophagocytic lymphohistioeytosis[J]. EurJ Pediatr, 2007, 166: 95-109.
  • 4Nagafuji K, Nonami A, Kumano T, et al. Perfofin gene mutations in adult-onset hemophagocytic lymphohistiocytosis [J]. Haematologica, 2007, 92 (7) : 978-981.
  • 5Sato S, Kawashima H, Oshiro H, et al. Virological and immunological characteristics of a 19-year-old Japanese female with fatal outcome with Epstein-Barr virus-associated hemophagocytic syndrome[J]. J CIin Virol,2004,31 : 235-238.
  • 6Kasahara Y, Yachie A. Cell type specific infection of Epstein-Barr virus (EBV) in EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection [J]. Crit Rev Oncol Hematol, 2002,44: 283-294.
  • 7Shinsaka I. Clinical features and treatment strategies of EpsteinJ Barr virus-associated hemophagocytic lymphohistincytosis [J ]. Critic Rev Oncol/Hematol, 2002, 44: 259-272.
  • 8Tabata Y, Hibi S, Teramura T, et al. Molecular analysis of latent membrane protein 1 in patients with Epstein /Barr virus-associated hemophagocytic lymphohistiocytosis in Japan [J]. Leuk Lymphoma, 2000,38 : 373-380.
  • 9Jin YK, Xie ZD, Lu G, el al. Characterization of variants in the promoter of BZLF1 gene of EBV in nonmalignant EBV-associated diseases in Chinese children[J]. Virol J, 2010, 7:92.
  • 10Chuang HC, Lay JD, Hsieh WC, et al. Epstein-Barr virus LMP1 inhibits the expression of SAP gene and upregulates Thl cytokines in the pathogenesis of hemophagocytic syndrome [J]. Blood,2005, 106(9) : 3090-3096.

共引文献37

同被引文献52

  • 1白石香,後藤三枝.感染相关性噬血细胞综合征[J].日本医学介绍,2006,27(4):172-174. 被引量:7
  • 2郭霞,李强,周晨燕.儿童噬血细胞综合征41例临床分析[J].中华血液学杂志,2007,28(7):449-453. 被引量:26
  • 3Janka GE. Hemophagocytic syndromes. Blood Rev, 2007,21 ( 5 ) :245-253.
  • 4Freeman HR, Ramanan AV. Review of haemophagocytic lym- phohistiocytosis. Arch Dis Child ,2011,96 ( 7 ) :688-693.
  • 5Janka GE. Familial and acquired hemophagocytic lymphohistio- cytosis. Eur J Pediatr ,2007,166 (2) ..95-109.
  • 6Weitzman S. Approach to hemophagocytic syndromes. Hematol- ogy Am Soc Hematol Educ Program,2011,2011 ( 1 ) :178-183.
  • 7Chan JS, Shing MM, Lee V, et al. Haemophagocytic lymphohis- tiocytosis in Hong Kong children. Hong Kong Med J,2008,14 (4) :308-313.
  • 8Verbsky JW, Grossman WJ. Hemophagocytic lymphohistiocyto- sis: diagnosis, pathophysiology, treatment, and future perspec- tives. Ann Meal,2006,38( 1 ) :20-31.
  • 9Trottestam H, Berglof E, Home A, et al. Risk factors for early death in children with haemophagocytic lymphohistiocytosis. Acta Paediatr,2012,101 (3) :313-318.
  • 10Henter Jl, Home A, A_rico M, et al. HLH-2004 : Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer,2007,48 ( 2 ) : 124-131.

引证文献5

二级引证文献24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部