普瑞巴林对带状疱疹后遗神经痛神经阻滞效果的影响

Effect of Pregabalin on Nerve Block during the Treatment of Postherpetic Neuralgia

目的观察普瑞巴林对带状疱疹后遗神经痛神经阻滞效果的影响。方法将40例患者随机分为对照组(A组)和普瑞巴林组(B组),两组患者均行神经阻滞,B组加服普瑞巴林。对比观察两组患者用药前后VAS评分、睡眠质量评分(QS)和不良反应。结果与治疗前比较,两组治疗后第2周～第10周,VAS和QS显著下降(P<0.01)。普瑞巴林组治疗后疼痛VAS评分和睡眠质量评分均显著低于对照组(P<0.05)。两组不良反应的发生率没有区别。结论普瑞巴林对带状疱疹后遗神经痛的神经阻滞效果具有明显的增强作用。

OBJECTIVE To observe the effect of pregabalin on nerve block during the treatment of postherpetic neuralgia. METHODS All of 40 postherpetic neuralgia patients were divided randomly into two groups, the control group（A） and gabapentin group（B）. All patients were performed with nerve block, and the patients in group B received oral gabapentin. Visual analog scale （VAS） and sleep quality score （QS） were evaluated and adverse reactions were recorded. RESULTS VAS and QS in two groups decreased significantly after treatment, but VAS and QS of group B decreased more significantly than those of group A. There was no difference in adverse reactions between two groups. CONCLUSION The effect of pregabalin on nerve block during the treatment of postherpetic neuralgia is synergistic.