期刊文献+

用于治疗乳腺癌的抗体-药物共轭物Trastuzumab Emtansine 被引量:1

原文传递
导出
摘要 罗氏集团旗下的基因泰克公司和日本中外制药株式会社联合开发的Trastuzumabemtansine(T.DMl)为-新型抗体-药物共轭物,由直接作用于受体酪氨酸-蛋白激酶erbB.2(HER2)的抗体trastu—zumab与抗有丝分裂药物maytansine的衍生物emtansine(DMl)通过硫醚以共价键结合而成。
作者 邢爱敏
出处 《药学进展》 CAS 2012年第6期284-285,共2页 Progress in Pharmaceutical Sciences
  • 相关文献

同被引文献45

  • 1陈立波,朱瑞森.Bexxar治疗非霍奇金淋巴瘤的研究现状[J].国外医学(放射医学核医学分册),2005,29(2):67-70. 被引量:3
  • 2陈洁,钱其军,达万明.用于血液系统恶性肿瘤治疗的单克隆抗体[J].白血病.淋巴瘤,2005,14(4):248-251. 被引量:1
  • 3Papac RJ. Origins of cancer therapy [ J ]. Yale J Biol Med, 2001, 74(6) :391 -398.
  • 4Schrama D, Becker JC, Reisfeld RA. Antibody targeted drugs as cancer therapeutics[J]. Nat Rev Drug Dis,2006,5:147 - 159.
  • 5Litman GW, Rast JP, Shamblott M J, et al. Phylogenetic diversifi- cation of immunoglobulin genes and the antibody repertoire [ J]. Mol Biol Evol, 1993,10 ( 1 ) :60 - 72.
  • 6Cobleigh MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti - HER2 monoclonal antibody in women who have HER2 - overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease [ J ]. J Clin Oncol, 1999,17 (9) :2639 - 2648.
  • 7Johnson JR, Ford CH, Newman CE, et al. A vindesine - anti - CEA conjugate cytotoxic for human cancer cells in vitro[ J]. Br J Cancer, 1981,44 (3) :472 - 475.
  • 8Garnett MC. Targeted drag conjugates: Principles and progress [ J ]. Adv Drug Deliv Rev,2001,53 (2) : 171 - 216.
  • 9Maxfield FR, Mcgraw TE. Endocytic recycling [ J ]. Nature Rev Mol Cell Biol,2004,5:121 -132.
  • 10Singh R, Erickson HK. Antibody - cytotoxic agent conjugates: Preparation and characterization [ J]. Methods Mol Biol,2009,525 (4) :445 -467.

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部