宾阳县妇女儿童医院新生儿败血症血培养病原菌分布及耐药性分析

Analysis of the distribution and drug resistance of pathogens in blood culture of neonates with septicemia in Binyang County

目的分析宾阳县妇女儿童医院新生儿败血症血培养病原菌分布及耐药情况,以指导临床合理使用抗生素。方法对宾阳县妇女儿童医院新生儿科2008-10～2011-10新生儿败血症血培养检出菌和药敏实验结果进行了回顾性分析。结果临床诊断败血症的血液标本中培养出病原菌41株,其中革兰阳性菌32株(78.0%),革兰阴性菌9株(22.0%),排在前五位的菌种分别为表皮葡萄球菌14株(34.1%)、人葡萄球菌5株(12.2%)、金黄色葡萄球菌4株(9.8%)、肺炎克雷伯菌4株(9.8%)、大肠埃希菌3株(7.3%);葡萄球菌对青霉素耐药率高达100%。结论耐苯唑西林的凝固酶阴性葡萄球菌是该县新生儿败血症最常见的病原菌,对常用抗生素有不同程度的耐药,全面了解病原菌分布和耐药性,有利于提高新生儿科抗感染治疗的质量,对控制院内感染,延缓细菌耐药性发生有重要意义。

Objective To investigates the distribution and drug resistance of local area pathogens in neonates with septicemia in order to direct the clinical reasonable usage of antibiotics. Methods The result of detection and drug sensitivities of pathogens in the neonates with septicemia treated in our hospital from October 2008 to October 2011 were retrospectively analyzed. Results Out of the blood samplies,41 strains were detected,including Gram-pos- itive bacteria （32 strains, accounting for 78% ） and Gram-negative bacteria （9 strains, accounting for 22% ）. The five most common pathogens were Staphylococcus pidermidis （14 strains 34. 1% ）, Staphylococcus hominid （5 strains, 12. 2% ）, Staphylococcus aureus （4 strains, 9. 8% ） and Klebsiella pneumonia （4 strains, 9. 8% ）, Esche- richia coli （3 stains, 7. 3% ）. The resistance of staphylococcus to penicillin was 100%. Conclusion CNS is the most common pathogens of neonatal sepsis ; the common antibiotics have different levels of drug resistance. Investigating pathogenic bacteria distribution in the region and resistance change can improve neonatal anti-infection treatment quality, control nosocpmial infection, and delay the occurrence of bacteria resistance.