多拉菌素浇泼剂在犬体内的药代动力学

Pharmacokinetics of the Pour-on Preparation of Doramectin in Dogs

本试验对多拉菌素浇泼剂在犬血浆中的药代动力学进行了研究。犬背部皮肤一次浇注多拉菌素浇泼剂(0.1mg/kg体重),给药后,不同时间点从犬前肢静脉采血。以高效液相色谱法对血浆中药物浓度进行测定,血浆药物浓度—时间数据用WinNonlin 5.2.1的非房室模型药动软件处理。给药后的主要药物动力学参数为:t1/2β为(2.14±0.56)d,Tmax为(1.00±0.00)d,Cmax为(24.38±4.82)ng/mL,AUC为(89.79±16.90)ng/(d.mL)。提示多拉菌素浇泼剂在犬体内血药浓度维持的时间较长,消除缓慢。

Pharmacokinetics studies of pour-on of doramectin in dog blood plasma. Drow blood from the jugular vein of the dogs in different time after used the pour-on of doramectin one time on the skin of back with the concentration 0. 1 mg/kg · bw. We used the method of the HPLC to detect the concentration of the doramectin in the blood plasma. The blood plasma do- ramectin concentration and time data was processed by the non compartment analysis of the WinNonlin5, 2. 1 software. The main pharmacokinetic parameters were the maximum concentration （Cmax） Of the doramectin in the blood plasma is （24.38 ±4.82）ng/mL, and the time is （1.00±0.00） d （Tmax）after we used the doramectin pour-on. The elimination half life （t1/2β） is （2.14±0.56） d. Area under curve （AUC） is （89.79±16.90） ng/（d · mL）. The results showed that doramectin has a long persistence in the plasma concentrations and eliminated slowly in dogs.