哺乳动物的外周味觉受体和信号转导及调节机制

Taste receptors,signal transduction and modulation mechanism of mammalian taste buds in the periphery

味觉是一种极为复杂和重要的感觉。哺乳动物借助高度敏感专一的味觉感受器,对外界环境中的化学物质进行识别、探寻食物和调节食欲并作出相应的好恶甚至规避性的行为应答。味觉信号转导机制是目前口腔基础研究领域的热点和难点。在过去的数年里,味觉受体、信号转导及调节机制受到了极大的关注,本文就味觉细胞的类型和功能、外周味觉受体及信号转导机制、外周味觉信号调节机制研究进展作一综述。

Taste is a very complex and important sense. With the help of highly sensitive and specific taste receptors, mammals identify the chemical substance, search for food, regulate appetite and make corresponding likes and dislikes or even avoiding behavioral responses. At present, taste signal transduction mechanism is hot and difficult in basic research of stomatology. In the past few years, taste receptors, signal transduction and regu- lation mechanism had received considerable attention. In this paper, the research progress on type and function of taste cell, taste receptors, singnal transduction and modulation mechanism in the periphery are reviewed.