知柏地黄丸联合派丽奥软膏治疗慢性牙周炎的疗效及龈沟液中炎性因子的影响

Therapeutic Effect of Chronic Periodontitis with Zhibai Dihuang Pills Combined with Periocline and its Effect on Inflammatory Factor in Gingival Crevicular Fluid

目的:知柏地黄丸联合派丽奥软膏治疗慢性牙周炎的疗效及龈沟液中炎性因子的影响。方法:采用随机分组对照试验,治疗组给予派丽奥软膏注入牙周袋内,直至药物由袋口溢出,1次/周,同时加服知柏地黄丸8丸/次,3次/日,对照组给予常规治疗,比较两组患者的治疗效果和炎性因子的变化。结果:治疗组和对照组的总有效率分别为96.3%和81.5%,治疗组疗效明显优于对照组(P<0.05)。治疗前,治疗组和对照组的龈沟出血指数(SBI),菌斑指数(PLI)、龈沟出血指数(SBI),探诊深度(PD),附着丧失(AL),白细胞介素(IL)-6,白细胞介素(IL)-8,肿瘤坏死因子(TNF)-α相比均无明显的差异性。第5周时,治疗组与对照组的各项指标与治疗前相比均有明显降低(P<0.05,P<0.01);治疗后,治疗组的SBI,PD,AL,PLI,L-6,IL-8,TNF-α较对照组明显降低(P<0.05)。结论:知柏地黄丸联合派丽奥软膏治疗慢性牙周炎疗效显著,可作为治疗慢性牙周炎的一种有效方法。

Objective： Explore the therapeutic effect of chronic periodontitis with Zhibai Dihuang pills （ZDP） combined with periocline and its effect on inflammatory factor in gingival crevicular fluid. Method： Two hundreds and fourteen patients with chronic periodontitis were randomly divided into treatment group and control group, the patients in treatment group injected Periocline into the periodontal pocket until the drug pocket overflow, once a week, and ZDP （3# Tid）, the patients in control group received routine therapy, the therapeutic effect and changes of inflammatory factor were observed after treatment. Result： The total effective rates of the treatment group by 96. 3%were higher than that of the control group by 81.5% （P 〈0. 05）. The levels of sulcus bleeding index （SBI）, sulcus bleeding index （ SBI）, probing depth （PD）, attachment loss （AL）, plaque index （ PLI）, interleukin-16 （IL-6）, interleukin-8 （IL-8）, tumor necrosis factor-α （TNF-α） had no significant difference between both groups before the treatment, after 4 weeks, the levels of those of both group were reduced significantly （P 〈0. 05, P 〈0. 01） ）. SBI, PD, AL, PLI, IL-6, IL-8, TNF-α was lowed in treatment group than those in the control group （P 〈0. 05）. Conclusion： The therapeutic effect of Zhibai Dihuang pills combined with periocline in treatment of chronic periodontitis is obvious, which is an effective method to chronic periodontitis.