藏药榜嘎化学成分和药理作用的研究进展

Research Progress on Tibetan Medicinal Herb Ponkar

总结藏药榜嘎在化学、药理和临床方面的研究进展。查阅国内外近年来的科技文献、书籍,并对其进行分析归纳。榜嘎中的化学成分主要包括生物碱类、黄酮类和挥发油类等成分,目前已分离到的生物碱有22个,黄酮有3个,挥发性成分35个。其主要活性集中在抗炎、抗病毒、抗癌等研究上,主要以复方的形式用于流行性感冒、各种炎症和病毒感染等的治疗。榜嘎的化学成分研究很少,活性研究仅限于粗提物的抗炎、抗病毒研究,作用机制和毒性研究极少,应加强榜嘎化学成分、有效部位和有效单体、作用机制及毒性研究,为扩大该药材的应用开发提供依据。

Objective： To summarize the research progress on chemical components, pharmacological actions and clinical utility of Herba Aconiti Ponka. Method ： Literatures about Ponka in plenty of scientific journals and books were referred to, and the progress of the chemical components, pharmacological actions and clinical utility were summarized. Result： Up to now, the chemical components isolated from Ponka mainly included 22 alkaloids, 3 flavonoids and 35 volatile oils. Pharmacological references showed that it exhibited various biological effects e. g. anti-inflammation, antivirus and anticancer. Clinical references showed that it is mainly used to treat influenza, pneumonia, hepatitis, common inflammation, as well as virus infection. Conclusion： It＇s not enough in the study of Ponka. In the future, we should focus on the chemical compositions, effective fractions and compounds, and the mechanism of actions and toxicology of Ponka, so that we can provide references and basis for the further application and exploitation for new drug development.