5Matloub Y,Lindemulder S, Gaynon PS, et al. Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intratheeal metho-trexate: results of the Children s Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemia, reported by the Childreffs Oncology Group[J]. Blood, 2006,108: 1 165-1 173.