土鳖虫水提物联合环磷酰胺抗肿瘤增效减毒作用研究

Anti-Tumor Effect of Aqueous Extracts from Eupolyphage sinesis Walker Combined with Cyclophosphamide

目的:探讨土鳖虫水提物对化疗药物环磷酰胺抗H22肿瘤的增效减毒作用。方法:将接种H22肿瘤的小鼠分为模型对照组、CTX组、土鳖虫水提物组和土鳖虫水提物+CTX组。给药10天,检测各组小鼠的抑瘤率、脾脏指数和胸腺指数,分析土鳖虫水提物对CTX的减毒增效作用。结果:土鳖虫水提物可抑制H22肿瘤的生长,抑瘤率为38.76%。单用CTX组抑瘤率为36.95%,联用土鳖虫水提物组抑瘤率为47.28%,与单用CTX组比较差异显著(P<0.01)。与模型组比较CTX组胸腺指数和脾脏指数显著降低,但联合土鳖虫水提物组的胸腺指数和脾脏指数与CTX相比显著升高(P<0.05)。结论:土鳖虫水提物对H22肿瘤具有抑制作用,对化疗药物CTX具有增效减毒作用。

Objective：To observe the effect of aqueous extracts from Eupolyphage sinesis Walker in enhancing the effect of chemotherapy and against its side - effect in H22 - bearing mice. Methods ： H22 - bearing mice were divided into 4 groups ： H22 control group, CTX group, the extract group and the extract combined with CTX group. After 10 -day treat- ment, the rate of tumor in inhibitory rate,indexes of thymus and spleen were calculated. Results ： The extract inhibited the growth of H22 in KM mice. The tumor inhibitory rate of aqueous extract was 38.76% ,of the extract combined with CTX was 47.38 %, which was higher than that of CTX administration alone （36.95%）. Compared with CTX group, the inde- xes of thymus and spleen were significantly elevated in the extract and CTX combination group（P 〈 O. 05 ）. Conclusion： The aqueous extract has anti - tumor effects on H22 - bearin~ mice and attenuation ~ff^ct~ ,n C.TX