摘要
目的:探讨土鳖虫水提物对化疗药物环磷酰胺抗H22肿瘤的增效减毒作用。方法:将接种H22肿瘤的小鼠分为模型对照组、CTX组、土鳖虫水提物组和土鳖虫水提物+CTX组。给药10天,检测各组小鼠的抑瘤率、脾脏指数和胸腺指数,分析土鳖虫水提物对CTX的减毒增效作用。结果:土鳖虫水提物可抑制H22肿瘤的生长,抑瘤率为38.76%。单用CTX组抑瘤率为36.95%,联用土鳖虫水提物组抑瘤率为47.28%,与单用CTX组比较差异显著(P<0.01)。与模型组比较CTX组胸腺指数和脾脏指数显著降低,但联合土鳖虫水提物组的胸腺指数和脾脏指数与CTX相比显著升高(P<0.05)。结论:土鳖虫水提物对H22肿瘤具有抑制作用,对化疗药物CTX具有增效减毒作用。
Objective:To observe the effect of aqueous extracts from Eupolyphage sinesis Walker in enhancing the effect of chemotherapy and against its side - effect in H22 - bearing mice. Methods : H22 - bearing mice were divided into 4 groups : H22 control group, CTX group, the extract group and the extract combined with CTX group. After 10 -day treat- ment, the rate of tumor in inhibitory rate,indexes of thymus and spleen were calculated. Results : The extract inhibited the growth of H22 in KM mice. The tumor inhibitory rate of aqueous extract was 38.76% ,of the extract combined with CTX was 47.38 %, which was higher than that of CTX administration alone (36.95%). Compared with CTX group, the inde- xes of thymus and spleen were significantly elevated in the extract and CTX combination group(P 〈 O. 05 ). Conclusion: The aqueous extract has anti - tumor effects on H22 - bearin~ mice and attenuation ~ff^ct~ ,n C.TX
出处
《中华中医药学刊》
CAS
2012年第6期1264-1265,共2页
Chinese Archives of Traditional Chinese Medicine
基金
江西省卫生厅科技计划资助项目(20092078)
九江学院大学生自主创新性项目(09XSCXXSY28)
关键词
土鳖虫水提物
环磷酰胺
增效减毒
aqueous extracts from Enpolyphage sinesis Walker
cyclophosphamide
synergism and attenuation