紫杉醇雾化吸入治疗肺部肿瘤的研究进展

Research Progress on Paclitaxel Aerosol Inhalation in Treating Pulmonary Neoplasms

肺部是原发性肺癌发生的部位,也是其他部位肿瘤常转移的地方。化学疗法广泛应用于肺部肿瘤的治疗,而紫杉醇雾化吸入治疗肺部肿瘤近来受到越来越广泛的关注。紫杉醇雾化吸入疗法具有全身不良反应小,药物局部浓度高的特点。目前紫杉醇雾化吸入的基础研究进行较多,临床研究相对较少,还有待进一步探讨。本文就紫杉醇雾化吸入治疗肺部肿瘤的研究进展作一综述。

Lungs are not only the site for primary lung cancer, but also a commom site for metastatic lung cancer. Chemotherapy is widely used in both primary and secondary lung carcinomas. Currently ,there is expanding interest in pa- elitaxel aerosol inhalation in treatment of pulmonary neoplasms. This treatment offers several theoretical advantages over systemic delivery,including the possibility of regional drug delivery to the lungs and airways with lower doses and fewer systemic side effects. At present, although there are many basic researches on paclitaxel aerosol inhalation, the develop- ment of clinical use has been limited, which requires great efforts for further studies. This article overviews the progress on paclitaxel aerosol inhalation treating pulmonary neoplasms.