逍遥丸加减联合心理疗法在肝郁脾虚型肠易激综合征的应用

Effect of Modified Xiaoyao Pill combined with Psychotherapy on Syndrome of Liver Depression and Spleen Deficiency of Diarrhea-dominant Irritable Bowel Syndrome

目的:观察逍遥丸加减联合心理疗法对大学生肝郁脾虚型肠易激综合征(腹泻型)的近期及远期疗效。方法:将60例患者随机分为两组,治疗组30例,运用逍遥丸加减治疗,每日1剂,早晚分服,治疗4周;对照组30例,口服马来酸曲美布汀,100mg/次,3次/天,饭前半小时温开水送服,治疗4周,两组患者均接受心理治疗,每周2次,治疗4周。观察大便性状评分,腹部综合征状等级评分和疗效评价。结果:两组Bristol评分及腹部症状评分均较治疗前明显降低(P<0.05),治疗组随访2个月在改善Bristol评分及腹部症状评分方面均优于对照组(P<0.05)。在临床疗效观察中两组之间无明显差异(P>0.05)。结论:逍遥丸加减联合心理疗法能较好的改善大学生肝郁脾虚型肠易激综合征(腹泻型)患者的症状。

Objective ：To observe the curative effect of modified Xiaoyao Pill combined with psychotherapy on relie- ving symptoms of patients with liver depression and spleen deficiency syndrome of diarrhea - dominant irritable bowel syn- drome（ D - IBS）. Methods ： 60 cases of D - IBS were randomly divided into two groups. Among them 30 cases were trea- ted with modified Xiaoyao Pill for 4 weeks. The other 30 cases were treated with Trimebutine - Maleate served as a con- trol group. All the patients received psychotherapy for 4 weeks, twice a week. The Bristol stool scale and abdominal symp- tom scores of both groups were documented respectively before and after treatment and 2 - month follow - up visit, as well as the curative effect. Results ： After treatment the score of Bristol stool and abdominal symptom in both groups had been significant decreased （ P 〈 0.05） the score of the treated group was lower than that of the controlled group in 2 - month follow - up visit （ P 〈 0.05 ） ; and there was no significant difference between these two groups in curative effect. Conclusion： Modified Xiaoyao Pill combined with psychotherapy can improve the symptom of liver depression and spleen deficiency syndrome of D - IBS oatients.