hK2、Ki-67在前列腺癌组织中的表达及其临床意义

Expression of hK2 and Ki-67 in prostate cancer and its clinical significance

目的探讨hK2、Ki-67基因在前列腺癌组织中的表达和临床意义。方法应用免疫组织化学SP法检测40例前列腺癌和30例前列腺增生组织中hK2和Ki-67基因的表达情况。结果前列腺癌组织中hK2、Ki-67的阳性表达率明显高于前列腺增生组织(P<0.05)。hK2阳性表达与前列腺癌的Gleason分级有关(P<0.05),与临床分期无关(P>0.05);Ki-67的阳性表达与Gleason分级无关(P>0.05),与临床分期有关(P<0.05)。hK2和Ki-67在前列腺癌组织中的表达呈正相关(P<0.05)。结论 hK2、Ki-67异常表达与前列腺癌的诊断及预后密切相关,联合检测二者的表达有可能作为前列腺癌诊断和预后评估的指标。

Objective To study the expression of hK2 and Ki-67 in prostate cancer and its clinical significance. Methods Expression of hK2 and Ki-67 was studied in tissues collected from 40 cases of prostate cancer（PCa） and 30 cases of benign prostatic hyperplasia（BPH） using the immunohistochemical SP method. Results The rates of hK2 and Ki-67 expression were significantly higher in PCa than in BPH （P〈0.05）.Positive expression of hK2 in PCa tissue correlated with Gleason grading （P〈0.05） but not with clinical stage（P〉0.05）,while positive expression of Ki-67 correlated with clinical stage（P〈0.05） but not with Gleason grading （P〉0.05）.Expression of hK2 positively correlated with expression of Ki-67（P〈0.05）. Conclusions Abnormal expression of hK2 and Ki-67 correlated closely with the diagnosis and prognosis of PCa.Combined detection of hK2 and Ki-67 may be useful as a marker for early diagnosis and prognostic evaluation of PCa.