成都地区褐家鼠种群对抗凝血类杀鼠剂的抗药性水平

Resistance of Rattus norvegicus to the anticoagulant rodenticides in Chengdu

目的测定成都市褐家鼠种群对抗凝血类杀鼠剂的抗药性水平,为鼠害控制提供依据。方法采用凝血反应法测定褐家鼠对杀鼠灵和溴敌隆的抗药性。结果成都地区褐家鼠对杀鼠灵ED50为0.873(雄)和1.439(雌)mg/kg;对溴敌隆ED50为1.091(雄)和1.296(雌)mg/kg。按照鼠药抗性委员会推荐的敏感褐家鼠基准,该鼠种群对杀鼠灵的抗性水平在0.578～0.676之间;对溴敌隆的抗性水平在2.125～2.321之间。结论成都地区褐家鼠种群对溴敌隆已产生抗药性,对杀鼠灵未产生抗药性;在鼠害治理中,杀鼠灵可作为替代药物。

Objective To Evaluate the resistance of Rattus norvegicus to warfarin and bromadiolone in Chengdu, providing information for the control of rodents in the area. Methods The resistance of R. norvegicus to warfarin and bromadiolone was tested with the BCR method. Results The 50% effective dose （ED50） of warfarin for R. norvigieus was 0.873 mg/kg for male and 1.439 mg/kg for female respectively, with that of bromadiolone being 1.091 mg/kg for male and 1.296 mg/kg for female. According to the baseline of susceptible R. norvegicus approved by ARRPC, the resistance level of the population was between 0.578 and 0.676 fold for warfarin and between 2.125 and 2.321 for bromadiolone. Conclusion R. norvigicus populations have developed resistance to bromadiolone in Chengdu, but not to warfarin, which can be used as an alternative rodenticide applicable to the control of rodents in Chengdu.