肺腺癌患者组织中肿瘤标志物P16和P53蛋白的表达及意义

Expression of tumor marker p16 and p53 proteins in lung adenocarcinoma tissues

目的:研究肺腺癌患者组织中P16和P53蛋白的表达及临床意义。方法:应用免疫组织化学方法对57例不同临床病理参数肺腺癌患者肺腺癌组织和癌旁组织中p16和p53基因表达产物进行检测,并进行比较。结果:肺腺癌组织中P16蛋白的阳性率为35.1%,明显低于癌旁组织59.6%;P53蛋白的阳性率为80.7%(46/57),明显高于癌旁组织42.1%(P<0.05)。P16和P53蛋白表达与肺腺癌分化程度、浸润深度及淋巴结有无转移有关(P<0.05)。结论:肺腺癌组织P16和P53蛋白的异常表达可能与其发生、发展和预后有关。

Objective： To study expression of tumor marker P16 and P53 proteins in the occurrence and development of lung adenocarcinoma. Methods：pl6 and p53 genes expressions were detected in 57 lung adenocarcinoma and pericarcinoma tissues by immunohistochemical method. The data were analyzed with clinical materials. Results： The positive rate of P16 protein expression was 21.1% （12/57） in lung adeno- carcinoma samples and was significantly lower than that in the pericarcinoma tissues 59.6% （34/57）. The positive rate of P53 protein expression was 80.7 % （46/57） in lung adenocarcinoma tissue, and significant- ly higher than those in pericarcinoma tissues （42.1~, 24/5, P^0.05）. The positive expressions of the P16 and P53 proteins were correlated with histological type and degree of differentiation of lung adenocar- cinoma and depth of invasion and lymph node metastasis （P〈 0.05）. Conclusions： The data suggest that abnormal expressions of tumor marker P16 and P53 proteins are closely correlated with the occurrence and development, malignancy degree, lymph node metastasis and prognosis of lung adenocarcinoma.