尿激酶加序贯抗凝治疗次大面积肺栓塞疗效分析

Analysis of therapeutic effect of urokinase combined with sequential anti-coagulation in submassive pulmonary embolism

目的:探讨尿激酶加序贯抗凝治疗次大面积肺栓塞的疗效。方法:108例次大面积肺栓塞患者随机分为两组,观察组采用尿激酶加序贯普通肝素进行溶栓治疗,对照组单纯使用低分子肝素钙行皮下注射抗凝治疗,观察两组的短期疗效。结果:研究显示,与对照组相比,观察组具有更明显的疗效(P<0.05),肺动脉压显著降低,栓子减少更明显。结论:统计分析显示,尿激酶加序贯抗凝于次大面积肺栓塞疾病的治疗方面具有更为明显的疗效,值得在临床实践中加以推广。

Objective： To investigate the therapeutic effects of urokinase combined with sequential anti-coagulation in submassive pulmonary embolism. Methods： A total of 108 submassive pulmonary em- bolism patients were divided into two groups randomly. The treatment group was treated with urokinase combined with sequential anti-coagulation and the control group was only treated with low molecular weight heparin calcium by subcutaneous injection. The short-term effects were compared between the two groups. Results. Compared with the control group, the observation group showed more curative effects （P 〈0.05）, the pulmonary artery pressure and emholus decreased apparently. Conclusions, Statistical analy- sis shows that, urokinase combined with sequential anti-coagulation has better therapeutic effects on sub- massive pulmonary embolism, thus it is worth of application in large scale.