肝素和硝酸甘油治疗重度子痫前期患者的疗效对比

Comparison of effect of heparin and nitroglycerin in the treatment of severe preeclampsia patients

目的:比较肝素和硝酸甘油治疗妇产科重度子痫前期患者的疗效。方法:回顾性分析250例妇产科重度子痫前期患者的临床资料,250例随机分为A、B两组,两组均予以解痉、镇静、降压、扩容、利尿等常规治疗,在此治疗基础上,A组采用肝素治疗,B组采用硝酸甘油治疗,比较两组孕妇、新生儿并发症发生率及临床疗效。结果:A、B组新生儿并发症的发生率分别为74.4%、41.6%,两组差异有统计学意义(χ2=27.603,P<0.001);A、B组孕妇并发症发生率分别为47.2%、25.6%,两组差异有统计学意义(χ2=7.750,P<0.05)。结论:运用硝酸甘油治疗妇产科重度子痫前期效果优于肝素治疗者,这有助于提高对硝酸甘油和肝素治疗妇产科重度子痫前期的认识,指导临床医生用药。

Objective; To compare the clinical effects of low-molecular-weight- heparin （LMWH） and nitroglycerin in the treatment of severe preeclampsia. Methods. A total of 250 eligible cases were randomly divided into two groups, and all were treated by conventional therapy such as spasmolysis, sedative, depressurization, fluid expansion, diuretic, etc. Besides, patients in group A were treated with hepa- rin, and patients in group B with nitroglycerin. Complication incidence of pregnancy women and neonates and clinical therapeutic effect were observed and compared. Results. The complications incidence of neo- nates and pregnancy women in nitroglycerin group were significantly lower than that in LMWH group （Z2 7. 750 and 27. 603, P=0.006and 0. 001, respectively）. Conclusions. The therapeutic effects in nitroglycerin group is better than LMWH group in the treatment of severe preeclampsia. Our study is helpful in usage of these two drugs.