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APPswe/PS1dE9双转基因鼠表型综述 被引量：10

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摘要 阿尔茨海默病(Alzheimer's disease,AD)是常见的神经系统退行性疾病,其病因除了与衰老有关以外,还与淀粉样蛋白前体(β-Amyloid precursor protein,APP)基因、早老素(presenilin,PS)1和2基因、载脂蛋白E(apolipoprotein E,APOE)基因和微管相关蛋白tau(microtubule-associated protein tau,MAPT)基因等的遗传缺陷密切相关。将上述突变基因转入动物体内建立AD转基因动物模型为AD发病机制和治疗的研究提供了新的平台。APPswe/PS1dE9双转基因鼠同时携带具有瑞典型突变位点(Swedish KM594/595NL)的人鼠嵌合型APP基因(Mo/Hu APP695)和具有第9个外显子(dE9)突变的人PS1基因,这两种突变基因共同作用,加速淀粉样蛋白(β-amyloid peptide,Aβ)的产生和沉积,在老年期出现认知功能障碍等行为学异常,较好地模拟了AD的病理特征和渐进性的病程,是常用的AD转基因动物模型。本文系统综述了APPswe/PS1dE9双转基因鼠在Aβ产生和沉积、行为学异常和神经元变性及缺失等方面的表型特点,为其更好地应用于实验室研究提供必要的信息。
作者 崔艳秋 郑焱 王晓民
机构地区 首都医科大学燕京医学院 首都医科大学基础医学院生理学系 教育部神经变性病学重点实验室
出处 《生理科学进展》 CAS CSCD 北大核心 2012年第3期211-215,共5页 Progress in Physiological Sciences
关键词 阿尔茨海默病 APPswe/PS1dE9双转基因鼠 淀粉样蛋白
分类号 R741 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献15

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同被引文献42

  • 1刘英,高璐,马丽香,林芮禾,刘惠婷,姚君如,陈祖林,李瑞锡,彭裕文.APP/PS1双转基因小鼠大脑皮质老年斑的病变对其学习记忆能力的影响[J].神经解剖学杂志,2007,23(3):225-231. 被引量：10
  • 2Alzheimer's Disease International:World Alzheimer Report 2015.
  • 3Machova E,Jakubik J,Michal P,et al.lmpairment ofmuscarinic transmission in transgenic APPswe/PSldE9 mice.Neurobiol Aging, 2008,29:368-378.
  • 4Chung E,Ji Y,Sun Y J,et al.Anti-PrP(C)monoclonal antibody infusion as a novel treatment for cognitive deficitsin an Alzheimer's Disease model mouse.BMC Neurosci,2010,11:130-141.
  • 5Scullion G A,Kendal D A,Marsden C A,et al.Chronic treatment with the alpha(2)-adrenoceptor antagonist fluparoxan prevents age- related deficits in spatial working memory in APP x PS1 transgenic mice without altering b-amyloid plaque load or astrocytosis.Neurop Harmacology,2011,60:223-234.
  • 6Gimbel D A,Nygaard H B,Coffey E E,et al.Memory impairment in transgenic Alzheimer mice requires cellular prion protein.J Neurosci,2010,30:6367-6374.
  • 7Hoyer S.Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease:therapeutic imphcations.Adv Exp Med Biol,2004,541:135-152.
  • 8Meredith N,Braskie,Arthur W,et al.Reeent Advances in Imaging Alzheimer's Disease.Journal of Alzheimer's Disease, 2013,33:313-327.
  • 9Kjell N,Christer H,Juha O R,et al.Radiopharma-ceuticals for positron emission tomography investigations of Alzheimer's disease.Eur J Nuel MedMol Imaging,2010,37:1575-1593.
  • 10Shankar Vallabhajosula.Positron Emission Tomography Radiopharma-ceutieals for Imaging Brain Beta-Amyloid.Seminars in Nucl Med,2011,41 (4):283-299.

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生理科学进展
2012年 第3期

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