糖尿病患者幽门螺杆菌感染情况及颈动脉粥样硬化相关因素研究

Helicobacter Pylori Infection in Patients with Diabetes Mellitus and the Related Factors of Carotid Atherosclerosis

目的探讨糖尿病(DM)患者幽门螺杆菌(H.pylori)感染情况及DM患者颈动脉粥样硬化(CAS)的相关因素。方法选取227例DM患者及436例正常对照者,对其H.pylori感染情况进行比较;DM组以是否有CAS分为CAS组和非CAS组,测量患者血压、血脂,了解吸烟、H.pylori感染情况,分析DM患者CAS相关因素。结果DM组H.pylori感染率(63.78%)高于对照组(52.06%),差异有统计学意义(P<0.05)。CAS组H.pylori感染率、男性患者比例、吸烟率、年龄、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、三酰甘油(TG)水平高于非CAS组,高密度脂蛋白胆固醇(HDL-C)水平低于非CAS组,差异均有统计学意义(P<0.05),两组饮酒情况及低密度脂蛋白胆固醇(LDL-C)水平差异无统计学意义(P>0.05)。Logistic回归分析显示,H.pylori感染、吸烟、年龄、SBP、TG、HDL-C与DM患者发生CAS有相关性,HDL-C为保护性因素。结论 DM患者H.pylori感染率高于正常人群,H.pylori感染、吸烟、年龄、SBP、TG、HDL-C与DM患者发生CAS有相关性,应重视H.pylori感染,予以积极治疗。

Objective To explore the helicobacter pylori（H.pylori）infection in patients with diabetes mellitus（DM）and to analyze the related factors of carotid atherosclerosis.Methods Totally 227 patients with DM and 436 healthy controls were included in our study,and the H.pylori infections were detected.DM groups was divided into carotid atherosclerosis（CAS）group and non-CAS group,we assessed the related factors of CAS in DM patients including blood pressure,blood fat,smoking and H.pylori infection.Results The H.pylori infection rate in DM group（63.78%）was significantly higher than that in control group（52.06%）.The patients in CAS group had statistically higher age,smoking rate,H.pylori infection rate,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,total cholesterol（TC）,triglyceride（TG）and more males as compared with those in non-CAS group,while high density lipoprotein cholesterol（HDL-C）was significantly lower than non-CAS group.There was no difference in alcohol consumption and low density lipoprotein cholesterol（LDL-C）between the two groups.Logistic regression analysis showed that H.pylori infection rate,smoking,age,SBP,TG,HDL-C were correlated with CAS in DM group,while HDL-C as a protective factors.Conclusion H.pylori infection rate in DM patients is higher than that in healthy individuals,and H.pylori infection rate,smoking,age,SBP,TG,and HDL-C can influence the development of CAS in DM patients.