低分子量肝素预防股静脉置管后血栓形成的临床疗效

Effect of low molecular weight heparin on prevention of deep vein thrombosis after femoral vein catheterization

目的观察低分子量肝素预防股静脉置管术后深静脉血栓形成的效果。方法 122例下肢深静脉置管患者随机分为治疗组(63例)和对照组(59例)。治疗组每日皮下注射低分子量肝素5000IU,对照组采取下肢主被动活动等常规预防方法。观察2组深静脉血栓的发生率及治疗组治疗前后凝血功能及血小板有无变化。结果治疗组有7例出现深静脉血栓,对照组有15例出现,2组间差异具有统计学意义(P<0.05)。治疗组治疗前后APTT、PT、INR、PLT均无显著差异。结论股静脉置管术后使用低分子量肝素可以有效预防下肢深静脉血栓形成。

Objective To observe the effect of low molecular weight heparin on prevention of deep vein thrombosis after femoral vein catheterization. Methods A total of 122 patients with femoral vein catheterization was divided randomly into a treatment group （63 cases） and a control group（59 cases）.The treatment group was given 5000IU low molecular weight heparin through hypodermic injection while the control group car- ried out the routine methods such as active and passive exercises of the lower limbs. Results 7 cases in the treatment group were found deep vein thrombosis while 15 cases in the control group. The difference was significant（P〈0.05）. The value of APTY in treatment group wash ＇t significantly dif- ferent between pre-treatment and post-treatment （P〉0.05） , so were PT,INR and PLT. Conclusion It is effective to use low molecular weight hep- arin to prevent deep vein thrombosis after femoral vein catheterization.