老年抑郁症患者血清细胞因子水平的检测及其临床意义

Change of the level of serum cytokine and its relationship with depression in elderly depressed patients

目的探讨老年抑郁症患者血清细胞因子IL-1β、TNF-α的水平变化及其临床意义。方法采用酶联免疫吸附法(ELISA)检测60例首发老年抑郁症组患者和60例健康老年人正常对照组的血清IL-1β、TNF-α的水平,采用汉密尔顿抑郁量表(HAMD)对老年抑郁症患者进行抑郁评分。结果老年抑郁症组患者血清IL-1β、TNF-α水平显著高于正常对照组(P<0.01)。其中重度抑郁组患者血清IL-1β、TNF-α水平显著高于轻、中度抑郁组患者(P<0.01),中度抑郁患者血清IL-1β、TNF-α水平与轻度抑郁组患者比较,差异具有统计学意义(P<0.01)。结论细胞因子IL-1β、TNF-α参与了老年抑郁症的发生和发展,细胞因子的血清水平一定程度上反映了老年抑郁症的严重程度;血清IL-1β、TNF-α可能是老年抑郁症的免疫学标志之一。

Objective To investigate the change of the level of serum cytokine and its relationship with depression in elderly de- pressed patients. Methods The levels of serum cytokine （TNF-a and IL-1β） was measured by enzymatic-linked immunosorbent assay （ELISA） in all cases including 60 first-episode elderly depressed patients and 60 healthy controls, elderly depressed patients were measured by Hamilton depression rating scale（HAMD）. Results The level of serum cytokine （TNF-ctand IL-113） in elderly depressed patients was significantly higher than that in healthy controls（ P 〈 0. 01 ）, and the levels of serum cytokine （TNF-ctand IL- l 13） in those with serious depression were higher than those with moderate and mild depression （P 〈 0. 01 ）, and that in moderate depression patients were higher than that in mild depression patients （P 〈 0. 01 ）. Conclusion Serum cytokines levels （TNF-ctand IL-1β） increased significantly in elderly depressed patients and they were associated with the degree of depression. Serum cytokines （TNF-a and IL-1β） maybe played an important role in pathogenesis of elderly depressed patients and may be immunological markers in elderly depression patients.