替吉奥化疗同步调强适形放疗治疗老年局部晚期直肠癌的疗效观察

Efficacy of S-1 plus intensity modulated conformal radiotherapy for the old patients with locally advanced rectal cancer

目的观察替吉奥(S-1、维康达,山东新时代药业有限公司生产)化疗同步调强适形放疗治疗老年局部晚期直肠癌的有效性和安全性。方法选择26例老年局部晚期直肠癌患者,给予替吉奥化疗,50mg/(m2.d),分2次口服,d1～d14,每21天为一周期。放疗结束后继续替吉奥化疗第二周期。化疗开始同步给予调强适形放疗,放疗剂量64～70Gy。对近期疗效及不良反应加以评价。结果完全缓解3例(11.5%),部分缓解13例(50%),稳定7例(26.9%),进展3例(11.5%),有效率为61.5%。主要毒性反应为血液学毒性、消化道反应、放射性皮炎,但均为Ⅰ级～Ⅱ级,可耐受。结论替吉奥化疗同步放疗治疗老年局部晚期直肠癌的效果较好,且患者可以耐受毒性反应。

Objective To evaluate the efficiency of S-1 plus intensity modulate conformal radiotherapy for the old patients with locally advanced rectal cancer. Methods 26 old patients with locally advanced rectal cancer were treated by combining chemotherapy （ S-1 ） and IMRT, their clinical date were analyzed. Results The complete response rates were 11.5% ,with part response rates were 50%. The major sides effects were hemopoietic toxicities,gastrointestinal reaction,skin radio reaction. Conclusion S-1 combineed with IMRT has a better efficacy for the old patients with locally advanced rectal cancer, and its toxicity is tolerable by the patient.