单纯超滤联合血液透析对透析低血压的干预作用

Intervention of sequential therapy of hemodialysis combined with simple ultrafiltration on hypotension in the process of hemodialysis

目的:观察单纯超滤联合血液透析序贯疗法对血液透析中低血压的干预作用。方法:将2009年1月至2011年11月入住郑州市第一人民医院的40例维持性透析患者,随机分为实验组和对照组,实验组20例采用单纯超滤联合血液透析序贯疗法,对照组20例采用常规血液透析治疗,比较2组患者透析中血压、临床症状和超滤量。结果:序贯透析患者透析低血压的平均水平为[(98±9)/(56±7)]mmHg,高于常规透析组[(85±21)/(55±8)]mmHg,但差异无统计学意义(P>0.05);序贯透析组透析低血压发生率为6.3%,较常规透析组(15.7%)明显减少(P<0.05),并且其透析充分性并没有降低。结论:单纯超滤联合血液透析序贯疗法对血液透析过程中的血液动力学具有稳定作用,可有效预防透析低血压,并提高血液透析效率。

Objective： To observe the intervention effect of the sequential therapy of hemodialysis combined with simple ultrafiltration on hypotension in the process of hemodialysis. Methods： 40 cases of hemodialysis patients from January 2009 to November 2011 were selected and randomly divided into the experimental group and the control group.The experimental group with sequential therapy of hemodialysis combined with simple ultrafiltration,and the control group with conventional hemodialysis.Blood pressure,clinical symptoms,and ultrafiltration volume were monitored and compared during hemodialysis for two groups of patients. Results： The average level of hypotension in the group of sequential therapy was [（98±9）/（56±7）] mmHg,which was higher than that in the control group [（85±21）/（55±8）] mmHg,while the difference between the two groups was not statistically significant（P0.05）.Hypotension incidence in the group of sequential therapy was 6.3%,which was lower than that in conventional dialysis group（15.7%）（P0.05）.And above all,its dialysis adequacy did not reduced. Conclusion： Sequential therapy of hemodialysis combined with simple ultrafiltration can keep blood dynamics stability in the process of hemodialysis,which can effectively reduce the incidence of dialysis hypotension and improve hemodialysis efficiency.