摘要
精原干细胞(spermatogonial stem cells,SSCs)是一群生活在睾丸特殊微环境中并能自我更新和具有多向分化潜能的细胞,是精子发生的基础。近年来,通过对SSCs表面的α6-和β1-整合素、CD9、GFRA1等主要标记分子,以及对GDNF、Plzf、泛素、LIF等决定SSCs自我更新和分化的多种细胞因子和基因的研究发现,目前在SSCs的分离、鉴定和生物学特性方面已获得新的成果。本文简述了目前哺乳动物SSCs主要的标记分子及自我更新与分化的调控机理,以期为该领域及其他干细胞研究提供一定的借鉴。
Spermatogonial stem cells （SSCs） are the foundation of spermatogenesis, a group of cells which live in a spe- cialized niche and have multiple differentiation potentiality. Recently, α6- and β-integrin, CD9, GFRA1 and other main molecular makers are regarded as the specific markers of SSCs, as well as the discovery of a variety of cytokines and genes, such as GDNF, Plzf, ubiquitin, LIF, which determine the self-renewal and differentiation of SSCs. New achievements have been reached on SSCs separation, identification and biological characteristics. This paper reviews the main molecular mak- ers and regulatory mechanism of serf-renewal and differentiation of SSCs at present, and provides further guidance for future studies of other stem cells.
出处
《四川动物》
CSCD
北大核心
2012年第4期679-683,687,共6页
Sichuan Journal of Zoology
基金
国家自然科学基金资助项目(No.30972097)
西北农林科技大学大学生科技创新资助
国家级动物科学实验教学示范中心建设项目资助
关键词
精原干细胞
调控机制
自我更新
分化
spermatogonial stem cells （SSCs）
regulatory mechanism
self-renewal
differentiation
