动物溶菌酶基因的研究进展

Research Progress on LYZ and its Gene in the Animal Kingdom

溶菌酶[Lysozyme(EC3.2.1.17),LYZ]是机体先天免疫系统中一个重要的效应分子,参与机体多种免疫反应,在溶菌过程中形成一个水解体系,破坏和消除侵入动物体内的病原,从而实现机体的免疫防御。它可以有效抑制葡萄球菌、大肠杆菌等一系列病原菌,是重要的奶牛乳房炎抗性因子之一。本文综述了溶菌酶基因的研究进展,包括其结构与进化、变异及应用前景等。

Lysozyme （LYZ, EC3. 2. 1. 17） is a key effective factor in body innate immune system, which participates in many kinds of body innate immune response. Lysozyme forms a hydrolyzed system when it plays a role in bacteriolysis. It damages and eliminates bacterial pathogens to realize body immune defense. Lysozyme is an important resistant factor of cow mastitis because of its effective inhibitory effect for many pathogenic bacteria such as Staphylococcus and Escherichia coli. This article reviews the advance of lysozyme gene features and its evolution, gene polymorphism and application prospect in animals.