氟比洛芬酯预防鼻内镜手术苏醒期躁动的临床研究

Flurbiprofen Axetil Injection in Preventing Restlessness During Analepsia from General Anesthesia in Functional Endoscopic Sinus Surgery

目的:评价氟比洛芬酯对鼻内镜手术患者全麻苏醒期躁动的预防作用。方法:42例ASA I-II级择期鼻内镜手术患者,随机分为试验组(麻醉开始前及手术结束前分别静脉给予氟比洛芬酯50mg,n=21);对照组(手术开始前及手术结束前静脉给予相同体积的生理盐水,n=21)。观察手术时间、麻醉维持时间、清醒时间及拔管时间;监测苏醒期心率(HR)、平均动脉压(MAP)、血氧饱和度(SpO2)及躁动评分、镇静评分;术后24 h随访副作用。结果:两组患者性别、年龄、体重、手术时间、拔管时间及苏醒时间差异无统计学意义;与对照组相比,试验组在术毕后各时点的HR、MAP均显著降低(P<0.05);两组患者在各观察时点的SpO2无统计学差异;试验组在各观察时点的躁动评分均显著低于对照组(P<0.05),Ramsay镇静评分均显著高于对照组(P<0.05);两组患者术后24 h内恶心呕吐发生率无明显差异。结论:静注氟比洛芬酯能安全有效预防鼻内镜手术全麻苏醒期躁动,不明显延长苏醒及拔管时间,不增加恶心呕吐发生率。

Objective： To evaluate the preventive effect of flurbiprofen axetil on restlessness during analepsia from general anesthesia in functional endoscopic sinus surgery.Method：42 patients with ASA grade I-II,undergoing selective functional endoscopic sinus surgery were randomly divided into test group and control group（n=21） ： In group I,flurbiprofen axetil（50mg） was administrated before anesthesia and before the end of operation.And in group II was given an equal volume of NS.HR,MAP,SpO2,Restlessness Score,Ramsay Sedative Score were monitored and assessed during the analepsia.Adverse effects were subsequently visted after operation.Result： There is no difference in gender,age,body weight,duration of operation,time for extubation and analepsia among two groups.HR and MAP in test group were lower than that in control group（P0.05）.There is no difference in SpO2 observed among two groups.Restlessness Score was apparently lower and Ramsay Sedative Score was significantly higher in test group than in control group（P0.05）.The rate of nausea and vomiting were not increased in test group during post-operative 24 h.Conclusion： It is safe and feasible of using flurbiprofen axetil to prevent restlessness during analepsia in functional endoscopic sinus surgery.