胎儿纤维连接蛋白联合解脲支原体检测用于预测早产的临床价值

The Clinical Value of Fetal Fibronectin and Ureaplasma Urealyticum in Predicting Preterm Delivery

目的:研究宫颈分泌物中胎儿纤维连接蛋白(FFN)和解脲支原体(UU)对先兆早产孕妇发生早产的预测价值,及联合检测是否提高对早产的预测。方法:对160例先兆早产孕妇的阴道分泌物分别用FFN快速测试条测定FFN和用PCR技术检测UU,并记录其妊娠结局。结果:在先兆早产孕妇中FFN检测阳性组与阴性组早产发生率比较,差异有统计学意义(P<0.01),UU检测阳性组与阴性组早产发生率比较,差异有统计学意义(P<0.01),UU阳性率及FFN阳性率之间的差异有统计学意义(P<0.01)。FFN灵敏度、特异度、阳性预测值、阴性预测值和约登指数均高于支原体,两者联合检测并联灵敏度达98.26%,串联特异度达92.39%。结论:FFN和UU在先兆早产中均是预测早产的较为敏感的指标,两者联合检测将提高预测早产能力。

Objective： To investigate the clinical value of cervical secretions fetal fibronectin（FFN）and Ureaplasma urealyticum（UU）in predicting preterm delivery and to observe FFN and UU combined detection to raise the accuracy of predicting preterm delivery.Method： To detect FFN and UU in 160 cases of threatened premature labor gravida,The pregnancy outcomes of the cases were tracked.Result： The incidence of preterm birth in the group of positive FFN was significantly higher than that in the group of negative FFN（P0.01）;The incidence of preterm birth in the group of positive UU was significantly higher than that in the group of negative UU（P0.01）;The positive rate of FFN was significantly higher than that of UU（P0.01）;The sensitivity,the specificity,the positive predictive value of FFN,the negative predictive value of FFN and Youden＇s index were higher than that of UU,The sensitivity of parallel test was 98.26%,the specificity of serial test was 92.39%.Conclusion： Both FFN and UU are sensitive indexes for predicting preterm delivery,The two indexes combined detection can raise the predicting ability of predicting preterm delivery.