对甲苯磺酸催化合成2,2-双(3-苯基-4-羟基苯基)丙烷研究

Studies on Synthesis of 2,2-Bis(3-Phenyl-4-Hydroxypheny) Propane Catalyzed by p-Toluenesulfonic Acid

以主催化剂对甲苯磺酸及助催化剂巯基丙磺酸来催化丙酮和邻苯基苯酚,经过缩合反应合成了2,2-双(3-苯基-4-羟基苯基)丙烷(双OPP-A),实验过程中研究了原料配比、反应温度、催化剂用量、反应时间等因素对产物的影响,得到合成2,2-双(3-苯基-4-羟基苯基)丙烷的最优工艺条件为:丙酮、邻苯基苯酚、对甲苯磺酸和巯基丙磺酸物质的量比为1:4:0.25:0.25,最佳反应时间为7h、最佳反应温度为60℃,2,2-双(3-苯基-4-羟基苯基)丙烷收率达到74.2%,经重结晶纯度达99.5%。通过红外光谱、核磁共振和熔点等分析手段对产物结构进行了确证。

The 2,2 - bis （ 3 - phenyl - 4hydroxypheny） propane （ bis OPP - A） was synthesized from o - phenyl phenol （OPP） and acetone by using p -Toluenesulfonic acid as main catalyst and 3 - mercaptopropanesulfonic acid as promoter. The effects of the reaction temperature and reaction time, the dosages of p - toluene sulfuric acid and 3 - mercaptopropanesulfonic acid , the molar ratio of OPP to acetone on the yield of bis OPP - A were studied. The optimum conditions were found as follows： n （acetone） ：n（ o - phenyl phenol） ： n（ p - Toluenesulfonic cid） ： n（ 3 - mercaptopropanesulfonic acid） = 1：4：0.25：0.25, reaction time is 7h and reaction temperature is 60℃, and the yield of 2,2 -bis （3 - phenyl - 4hydroxypheny） propane is 74.2%, the purity of the product is 99.5%. The structure of obtained bisOPP- A was characterized by melting point, IR and 1H -NMR.