乙型肝炎血清学指标与肝组织纤维化分期的相关性

Analysis of correlation of serum markers and liver fibrosis stage in patients with chronic hepatitis B

目的:探讨乙型肝炎患者血清学指标与肝组织纤维化病理学分期的相关性。方法:对214例乙型肝炎患者肝组织活检后进行常规病理检查,同时检测其血清肝纤维化指标、生化指标、凝血指标。比较分析各项检测项目与肝组织纤维化分期之间的相关性。结果:肝纤维化病理学分期与透明质酸、层黏连蛋白、Ⅳ型胶原、Ⅲ型前胶原等血清学指标之间的差异均有统计学意义(P<0.01)。结论:透明质酸、层粘连蛋白、Ⅳ型胶原、Ⅲ型前胶原等血清学检测项目的联合检测,可有效地辅助诊断乙型肝炎患者肝纤维化程度,并预测肝纤维化发展的趋势。

Objective： To investigate the correlation of serum markers and liver fibrosis pathological stage in patients with cbronic hepatitis B. Methods：The routine pathological examination of liver biopsy was tested in 214 cases of hepatitis B patients, the serum markers of liver fibrosis and liver function parameters, blood coagulation index and HBV-DNA level were also measured. The correlation of the test items and liver fibrosis stage was discussed. Results： There were statistical differences about hyaluronic acid, laminin, Ⅳ collagen, Ⅲ procollagen and other 10 test items with pathological stages of liver fibrosis （P 〈 0.01 ）. Conclusions： Hyaluronie acid, laminin, collagen IV, collagen Ⅲ and other serum test could be effective in diagnosis of hepatitis B patients with liver fibrosis, and they can predict the trend of liver fibrosis.