摘要
目的探讨体外培养子宫腺肌病在位内膜中腺细胞增殖对疾病的影响。方法用反转录-聚合酶链反应半定量分析ki-67mRNA在病例组与肌瘤组子宫内膜腺细胞的表达。结果病例组增生期和分泌期腺细胞均较肌瘤组表达ki-67mRNA增强(P<0.05)。结论子宫内膜腺细胞增殖能力增强可能是子宫腺肌病的发病机制之一。
Objective To explore the proliferation of the glandular epithelium cells of endometrium in adenomyosis and control group. Methods To analyze the expression of Ki-67mRNA in the above-mentioned two groups by semiquantitative RT-PCR. Results In both of proliferative and secretory phase, the expression of ki-67 mRNA in the glandular epithelium cells of adenomyosis group is stronger than that in control group（P〈0.05）. Conclusion The enhancement of proliferation in the glandular epithelium cells of endometrium of adenomyosis may be the one of the pathogenesis in adenomyosis.
基金
山西省科技厅攻关项目(042024-2)
