头孢呋肟钠与常用输液配伍的稳定性

Stability Inspect of Sodium Zinessafate Compatibility with common Infusion

目的 :模拟临床应用 ,在25℃条件下 ,将注射用头孢呋肟钠与常用输液配伍 ,观察配伍后的外观、微粒、内毒素、pH值变化及含量测定。方法 :采用紫外分光光度法进行光谱扫描和测定。结果 :8小时内各混合液均澄明、无颜色改变 ,微粒和内毒素检查符合规定 ,pH值无明显改变 ,吸收光谱和含量基本无变化。结论 :头孢呋肟钠可与常用输液配伍。

Purpose: To observe under the analogous clinical condition of 25oC on the compatibility between Sodium Zinessafate for infusion and common used infusion. Compare the changes of appearance, particle amount, PH value and content level before and after the infusions-combination. Method: UV spectrophotometry has been applied in the spectrum scanning and determination. Results: No changes was observed in clarity and color 8 hrs after mixing. The particle number and endotoxin test complied with the norm.. No significant change noted in PH value, absorption spectrum and content level before and after mixing. Conclusion: Sodium Zinessafate is compatible with common used infusion.