冠心病患者血清中IgE表达水平的意义

Changes of Peripheral Blood Levels of Total Immunoglobulin E in Patients with Coronary Heart Disease

目的:观察不同类型冠心病患者血清中IgE表达水平的意义。方法:将按美国心脏病学会/美国心脏病协会冠心病处理指南的诊断标准并经冠状动脉造影检查确诊的42例冠心病患者,分为稳定型心绞痛(SA)组20例,急性冠脉综合征(ACS)组22例;并选择冠状动脉造影正常的20例非冠心病患者作为对照组。采用ELISA法测定三组血清总IgE的水平。结果:ACS组患者血清总IgE水平为(113.55±18.61)IU/ml,明显高于对照组的(47.10±13.75)IU/ml和SA组的(51.35±13.57)IU/ml(P<0.01);SA组患者IgE水平高于对照组,但差异无统计学意义(P>0.05)。结论:随着冠心病病情加重,冠心病患者外周血中IgE表达水平升高,其可表达水平可能反映冠心病危险分层,IgE在冠心病中的作用仍有待进一步研究。

Objective ：To investigate the expression level of IgE in peripheral blood of patients with different types of coronary heart disease. Methods ：42 patients were diagnosed as coronary heart disease （CHD） acocording to the results of coronary angiography.42 patients were divided into two groups：stable angina（SA） group （n=20）, acute coronary syndrome（ACS）group （n=22）.Another 20 patients with normal coronary angiography served as control group.Serum total IgE levels was detected by ELISA method.Results ：The serum total IgE levels in ACS group was significantly higher than that in SA group （113.55 ± 18.61 IU/ml vs 51.35 ± 13.57 IU/ml, P〈0.01）.The serum total IgE levels in ACS group was significantly higher than that in control group（113.55 ±18.61IU/ml vs 47.10 ± 13.75 IU/ml, P〈0.01）.But no significant change was seen between in control group and in SA group（P〉O.05）. Conclusion：The expression level of IgE is significantly increased in patients with ACS in this study. It may reflect the risk stratification of coronary heart disease.The role of IgE remains to be further studied in coronary heart disease.