胃粘膜内肥大细胞及其脱颗粒在HP致病中的作用

A STUDY ON THE ROLES OF MAST CELLS AND THEIR DEGRANULATION IN GASTRIC MUCOSA IN THE PATHOPOIESIS OF H. PYLORI

目的 :探讨胃粘膜肥大细胞及其脱颗粒在HP感染中的致病作用。方法 :采用改良甲苯胺兰染色法检测了 14 2例患者胃粘膜中肥大细胞及其脱颗粒情况。结果 :HP阳性者胃粘膜内肥大细胞总数 ( 8.11)及脱颗粒比值 ( 4 7.65 % )均显著高于HP阴性者 ( 4 .2 2 ,3 1.3 2 % ) (P <0 .0 1) ;慢性活动性胃炎及中重度胃炎胃粘膜内肥大细胞总数 ( 8.73 ,8.79)及脱颗粒比值 ( 5 7.4 2 % ,5 7.74 % )均显著高于非活动性胃炎 ( 5 .5 4 ,3 5 .0 1% )和轻度胃炎 ( 5 .68,3 5 .5 6% ) (P <0 .0 1～ 0 .0 0 1)。结论 :肥大细胞及其脱颗粒参与了HP的致病过程而导致胃粘膜损伤。

Objective: To study the roles of mast cells and their degranulation in gastric mucosa in the pathopoiesis of H. Pylori. Methods Adopting improved Toluidine Blue Staining, we examined the gastric mucosal mast cells (MC) and their degranulation in 159 patients. Results The total amount of gastric mucosal MC (8.11) and the degranulation portion (47.65%) in the patients with positive H. Pylori were significantly higher than that in the patients with negative H. Pylori (4.22 and 31.32%) respectively ( P <0.01). The above two parameters in chronic active gastritis (8.73, 57.42%) and in moderate-severe gastritis (8.79,57.74%) were significantly higher than those in inactive gastritis (5.54,35.01%) and in mild gastritis (5.68, 35.56%) respectively ( P <0.01 or P <0.001). Conclusions MC and its degranulation in gastric mucosa may participate in the pathopoiesis of H. Pylori and cause gastric mucosal injury.