微量14碳-尿素呼气试验诊断幽门螺杆菌的研究

RELIABILITY OF 14C-UREA BREATH TEST (UBT) IN THE DETECTION OF HELICOBACTER PYLORI INFECTION

目的 :评估微量碳 -尿素呼气试验 ( 14C -UBT)诊断幽门螺杆菌 (HP)感染的可靠性。方法 :对 90例因上消化道不适而进行胃镜检查的患者 ,于胃窦部取多块活检标本进行组织学、粘膜涂片染色和快速尿素酶试验 ,以决定是否感染HP ,并作 14C -UBT。结果 :14C -UBT的敏感性、特异性及准确性是与组织学以及尿素酶方法检测HP的检测结果相比较而得到的。 14C -UBT的敏感性为 98.0 4 % ,准确性为 97.78% ,特异性为10 0 %。 90例患者中有 1例假阴性 ,但没有发现假阳性。结论 :微量 14C -UBT有高度敏感性和特异性 ,对确定患者的HP感染状态来说是一种无创而又非常可靠的诊断方法。

Objective: To assess the reliability of 14C-Urea Breath Test (UBT) in the detection of H-pylori infection. Methods: 90 patients with upper digestive tract discomfort were endoscopied and the status of H-pylori was detected by histodiagnosis, mucous smear staining and rapid urease test, as well as by 14C-UBT. Comparing with the histological examination and rapid urease test, the sensitivity, specificity and accuracy of 14C-UBT were obtained. Methods: The sensitivity and specificity of 14C-UBT were 98.0% and 100.0% respectively. The degree of H-pylori infection was highly related to the result of 14C-UBT. In these 90 cases, there was a false negative case but no false positive cases. Conclusions: Non-invasive 14C-UBT test is a highly sensitive and specific method for detecting H-pylori infection. It can be used as a conventional clinical test to detect H-pylori infection.