奎硫平合并西酞普兰治疗老年期抑郁症临床疗效观察

Observation of clinical curative effects on Quetiapine combined with Citalopram in the treatment of senile depression

目的探讨奎硫平合并西肽普兰治疗老年抑郁症的临床疗效和安全性。方法将60例老年抑郁症患者随机分为两组,每组30例。对照组口服西肽普兰,研究组口服西肽普兰合并奎硫平。于治疗前及治疗后1、2、4周和8周评定汉密尔顿抑郁量表(HAMD)、老年抑郁量表(GDS)、药物副作用症状量表(TESS)。结果在治疗老年期抑郁症中,研究组在临床疗效、HAMD、GDS评分方面与对照组比较,差异有高度统计学意义(P<0.01),而在药物副作用方面差异无统计学意义(P>0.05)。结论老年抑郁症患者,合用喹硫平治疗起效快,疗效好,安全性高,适宜临床使用。

Objective To investigate the clinical curative effects and safety of Quetiapine combined with Citalopram in the treatment of senile depression. Methods Sixty patients with senile depression were randomly divided into two groups, with 30 patients in each group. The control group received the oral administration of Citalopram and the study group received the oral administration of Quetiapine combined with Citalopram. The Hamilton depression rating scale （HAMD）, geriatric depression scale （GDS） and drug side effects symptom scale （TESS） were used for assessment before the treatment and 1, 2, 4 and 8 weeks after treatment. Results In the treatment of patients with senile depression, the study group was significantly different from the control group in the HAMD and GDS scores （P 〈 0.01）, but not significantly different in the drug side effects （P 〉 0.05）. Conclusion In the treatment of patients with senile depression, Quetiapine combined with Citalopram is fast, effective and safe, thereby suitable for clinical application.