玫芦消痤膏联合地氯雷他定治疗64例糖皮质激素依赖性皮炎临床研究

Clinical investigation of Meiluxiaocuo Cream and Desloratadine in the treatment of 64 cases with glucocorticoids dermatitis

目的探讨玫芦消痤膏联合地氯雷他定治疗糖皮质激素依赖性皮炎的临床疗效。方法选择2009年2月～2011年8月在我院皮肤科门诊就诊的64例糖皮质激素依赖性皮炎患者,将其随机分为两组,对照组(32例)口服5 mg地氯雷他定,1次/d;研究组(32例)在对照组治疗的基础上加用玫芦消痤膏局部外用,早中晚各1次。治疗1个月后进行临床疗效评价。结果治疗后研究组症状积分明显低于对照组,两组比较差异有统计学意义(P<0.05),两组症状积分差值在治疗前后比较差异有统计学意义(P<0.05)。研究组治疗有效率(84.38%)明显高于对照组的53.13%,两组比较差异有统计学意义(P<0.05),并且没有明显不良反应发生。反弹现象研究组明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论玫芦消痤膏联合地氯雷他定治疗糖皮质激素依赖性皮炎临床疗效确切,并且没有不良反应发生。

Objective To study the clinical curative effect of Meiluxiaocuo Cream and Desloratadine in the treatment of glucoeorticoids dermatitis. Methods 64 cases with glucoeortieoids dermatitis were randomly divided into two groups （research group and control group）, with 32 patients in each group. The control group was treated with Desloratadine （5 mg, once a day）. On the basis of the treatment, the research group was given Meiluxiaocuo Cream （three times a day）. The clinical curative effect was evaluated after treatment for one month. Results The symptom integral of research group was significantly lower than the symptom integral of control group, with statistically significant differences （P 〈 0.05）. The symptom integral difference of the two groups before and after treatment were significant different （P 〈 0.05）. The effective rate of research group （84.38%） was significantly higher than the effective rate of control group （53.13%）, with statistically significant differ- ences （P 〈 0.05）. All cases didn＇t appear adverse reaction. The rebound phenomenon of research group was significantly lower than rebound phenomenon of control group, with statistically significant differences （P 〈 0.05）. Conclusion Meiluxiaocuo Cream and Desloratadine have sure curative effect in the treatment of glucocorticoids dermatitis and they have no adverse reactions, the clinical implementation should be promoted.