摘要
了解国产盐酸艾司洛尔(简称E)预防气管插管引起心血管反应的临床效果。方法:90例全麻病人随机分为3组,A组E1.0mg/kg,B组E2.0mg/kg,C组生理盐水10ml。观察基础值、插管前、插管后1、2、3、5、10、15分钟3组HR、SBP、DBP、RPP变化。结果:A、B两组给E后HR减慢,插管后1~10分钟与C组比较均有显著差异(P<0.05);C组插管后SBP在1~10分钟显著高于插管前(P<0.05),与A、B两组比较有显著差异(P<0.05 );C组插管后DBP增高(P<0.01);5和10分钟时高于A、B两组(P<0.05);A、B两组RPP值始终<1600;C组插管后1~5分钟RPP均>1600(P<0.01),至10分钟仍高于A、B两组(P<0.05)。A组与B组之间 HR、SBP、DBP、RPP均无统计学差异。结论:艾司洛尔可减轻气管插管时的心血管反应。
To establish the clinical effects of hydrochlorate esmolol for prevention cardiovascular re ponse to tracheal intubation.Methch: Ninty patients teceiving general anesthesia randomly divided into three groups. The patients in group A received esmolol 1.0mg· kg-1; in group B esmolol 2. 0mg·kg-1; in group C saline 10ml. The HR, SBP, DBP and RPP at base, before intubation and at 1, 2, 3, 5, 10and 15minute after intubation were observated. Results: The HR from 1 to 10 minute after intubation in group A and B were singnificantly slower than those in group C (P < 0. 05). The SBP and DBP fm 1 to 10 minute after intubation in group C were singnificantly higer than before intubation (P < 0. 05) and than those in group A and B (P < 0. 05). The RPP in group A and B were lower than 1600 all the time. the RPP after inrubation in group C was higer than fan(P< 0. 01) and were higer(P < 0. 05) as compared with those in group A and B (P < 0. 05). All datas between group A and B were no singnificant change. Conclusion: Esmolol can reduce the cardiovascular response caused by tracheal intubation.
出处
《浙江临床医学》
2000年第2期84-86,共3页
Zhejiang Clinical Medical Journal
关键词
艾司洛尔
气管插管
心血管反应
Esmolol Tracheal intubation Cardiovascular response