艾司洛尔预防气管插管所致心血管反应的观察

Observation of esmolol for prevention haemodynamic response to tracheal intubation

了解国产盐酸艾司洛尔（简称Ｅ）预防气管插管引起心血管反应的临床效果。方法：９０例全麻病人随机分为３组，Ａ组Ｅ１．０ｍｇ／ｋｇ，Ｂ组Ｅ２．０ｍｇ／ｋｇ，Ｃ组生理盐水１０ｍｌ。观察基础值、插管前、插管后１、２、３、５、１０、１５分钟３组ＨＲ、ＳＢＰ、ＤＢＰ、ＲＰＰ变化。结果：Ａ、Ｂ两组给Ｅ后ＨＲ减慢，插管后１～１０分钟与Ｃ组比较均有显著差异（Ｐ＜０．０５）；Ｃ组插管后ＳＢＰ在１～１０分钟显著高于插管前（Ｐ＜０．０５），与Ａ、Ｂ两组比较有显著差异（Ｐ＜０．０５ ）；Ｃ组插管后ＤＢＰ增高（Ｐ＜０．０１）；５和１０分钟时高于Ａ、Ｂ两组（Ｐ＜０．０５）；Ａ、Ｂ两组ＲＰＰ值始终＜１６００；Ｃ组插管后１～５分钟ＲＰＰ均＞１６００（Ｐ＜０．０１），至１０分钟仍高于Ａ、Ｂ两组（Ｐ＜０．０５）。Ａ组与Ｂ组之间 ＨＲ、ＳＢＰ、ＤＢＰ、ＲＰＰ均无统计学差异。结论：艾司洛尔可减轻气管插管时的心血管反应。

To establish the clinical effects of hydrochlorate esmolol for prevention cardiovascular re ponse to tracheal intubation.Methch: Ninty patients teceiving general anesthesia randomly divided into three groups. The patients in group A received esmolol 1.0mg· kg-1; in group B esmolol 2. 0mg·kg-1; in group C saline 10ml. The HR, SBP, DBP and RPP at base, before intubation and at 1, 2, 3, 5, 10and 15minute after intubation were observated. Results: The HR from 1 to 10 minute after intubation in group A and B were singnificantly slower than those in group C (P < 0. 05). The SBP and DBP fm 1 to 10 minute after intubation in group C were singnificantly higer than before intubation (P < 0. 05) and than those in group A and B (P < 0. 05). The RPP in group A and B were lower than 1600 all the time. the RPP after inrubation in group C was higer than fan(P< 0. 01) and were higer(P < 0. 05) as compared with those in group A and B (P < 0. 05). All datas between group A and B were no singnificant change. Conclusion: Esmolol can reduce the cardiovascular response caused by tracheal intubation.