期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

食管鳞癌中p53、p57^(Kip2)和CD68的表达及其临床意义 被引量：1

Expressions and clinical significances of p53,p57^(Kip2) and CD68 in esophageal squamous cell carcinoma
下载PDF
导出
摘要 目的探讨p53、p57Kip2和CD68蛋白在食管鳞癌组织中的表达及其与食管鳞癌生物学行为的关系。方法应用免疫组化SP法检测51例食管鳞癌组织中p53、p57Kip2和CD68蛋白的表达,并分析3种蛋白表达之间及其分别与临床病理特征之间的关系。结果食管鳞癌组织中p53、p57Kip2和CD68的阳性表达率分别为64.71%、45.09%和58.82%;p53和CD68表达与分化程度、淋巴结转移及TNM分期有关(P<0.05);p57Kip2的阳性表达与分化程度和淋巴结转移有关(P<0.05),与TNM分期无关(P>0.05)。p53阳性表达者的p57Kip2阳性表达率为24.24%,明显低于p53阴性表达者的83.33%(P<0.05);CD68阳性表达者的p57Kip2阳性表达率为20.00%,亦明显低于p53阴性表达者的80.95%(P<0.05)。结论 p57Kip2与CD68、p53在食管鳞癌中的表达呈负相关,3项指标联合检查有助于判断患者的预后。 Objective To investigate the expressions of p53, p57Kip2 and CD68 in esophageal squamous cell carcinoma and their correlation with the biological behavior of esophageal squamous cell carcinoma. Methods The protein expressions of p53, p57KiP2and CD68 were detected in 51 cases of esophageal squamous cell carcinoma with SP immunohistochemical method. Results The positive rates of p53, p57KiP2 and CD68 were 64. 71% , 45.09% and 58.82% respectively in esophageal squamous cell carcino- ma. The positive expressions of p53 and CD68 were related to differentiation and TNM staging of esophageal squamous cell carcinoma, but p57 Kip2 was not related to TNM staging（P 〉 0. 05 ）. The positive expression rate of p57Ki~ was significantly lower in the positive p53 of esophageal squamous cell carcinoma than that in the negative （P 〈 0. 05 ）. The positive expression rate of p57Kip2 was significantly lower in the positive CD68 of esophageal squamous cell carcinoma than that in the negative （ P 〈 0.05 ）. Conclusion There are sig- nificant negative correlations between p57Kip2 and p53 ,CD68 protein expression. Combined detection of three proteins has an important value in prediction of prognosis.
作者 苏赓 唐中明 莫秋荣 温伟
机构地区 广西壮族自治区民族医院病理科 广西胸科医院胸外科
出处 《临床肿瘤学杂志》 CAS 2012年第6期520-523,共4页 Chinese Clinical Oncology
关键词 食管鳞癌 P53 p57~Kip2 CD68 免疫组织化学 Esophageal squamous cell carcinoma p53 p57Kip2 CD68 Immunohistochemistry
分类号 R735.1 [医药卫生—肿瘤]
  • 相关文献

参考文献15

  • 1Goeman F,Otto K,Kyrylenko S. ING2 recruits histone methyhransferase activity with methylation site specificity distinct from histone H3 lysines 4 and 9[J].Bioch in Biophys Acta,2008,(10):1673-1680.doi:10.1074/jbc.M110.103499.
  • 2Oliveira LR,Ribeiro-Silva A,Zucoloto S. Prognostic significance of p53 and p63 immunolocalisation in primary and matched lymph node metastasis in oral squamous cell carcinoma[J].Acta Histochemica,2007,(05):388-396.doi:10.1016/j.acthis.2007.03.006.
  • 3Hoekstra JW,Kummer JA,van Es RJ. Late(》5years)regional lymph node metastasis of oral sqauamous cell carcinoma(SCC),proven by p53 mutation analysis[J].Journal of Cranio-Maxillofacial Surgery,2008,(07):415-418.doi:10.1016/j.jcms.2008.04.002.
  • 4Ruddell A,Kelly-Spratt KS,Furuya M. P19/Arf and p53 suppress sentinel lymph node lymphangiogenesis and carcinoma metastasis[J].Oncogene,2008,(22):3145-3155.doi:10.1038/sj.onc.1210973.
  • 5Coffelt SB,Hughes R,Lewis CE. Tumor-associated macrophages effectors of angiogenesis and tumor progression[J].Bioch in Biophys Acta,2009,(01):11-18.doi:10.1016/j.jbiomech.2010.03.048.
  • 6Zhang BC,Gao J,Wang J. Tumor-associated macrophages infihration is associated with peritumoral lymphangiogenesis and poor prognosis in lung adenocarcinoma[J].Medical Oncology,2011,(04):1447-1452.
  • 7Mantovani A,Sozzani S,LocatiM. Macrophage polarization tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes[J].Trends in Immunology,2002,(11):549-555.doi:10.1016/S1471-4906(02)02302-5.
  • 8Sica A,Schioppa T,Mantovani A. Tumor-associated macrophages are a distinct M2 polarised population promoting tumor progression potential targets of anticancer therapy[J].European Journal of Cancer,2006,(06):717-727.doi:10.1016/j.ejca.2006.01.003.
  • 9Matsuooka S,Edwards MS,Bai C. p57kip2 structurally distinctmember of the P21 cipl-CDK inhibitor family,is a candicate tumor suppressor gene[J].Genes and Development,1995,(06):650-662.doi:10.1101/gad.9.6.650.
  • 10Ito Y,Takeda T,Sasald Y. Expression of p57kip2 protein in extrahepatic bile duct carcinoma and intrehepatic cholangiocellular carcinoma[J].Liver,2002,(02):145-149.

同被引文献14

  • 1Horre N, van Diest P J, van der Groep P, et al. Progressive de- railment of cell cycle regulators in endometrial carcinogenesis [ J ]. J Clin Pathol, 2008,61 ( 1 ) :36 -42.
  • 2Lai C H, Wang C J, Chao A. The clinical management of endom- etrial cancer in young Women [ J ]. Curr Obstet Gynecol Rep, 2013,2(1) :26 -31.
  • 3Xu X Y, Wang W Q, Zhang L, et al. Clinical implications of p57kip2 expression in breast cancer[ J ]. Asian Pac J Cancer Prev, 2012,13(10) :5033 -6.
  • 4Zhou Y, Shen J, Xia L, Wang Y. Estrogen mediated expression of nucleophosmin 1 in human endometrial carcinoma clinical stages through estrogen receptor-c signaling[ J ]. Cancer Cell Int, 2014, 14(1) :540.
  • 5Matsuoka S, Edwards M C, Bai C, et al. p57kip2, a structurally distinct member of the p21CIPI CDK inhibitor family, is a candi-date tumor suppressor gene [ J ]. Genes Dev, 1995,9 (6) : 650 - 62.
  • 6Borriello A, Caldarelli I, Bencivenga D, et al. p57 ( Kip2 ) and cancer: time for a critical appraisal [ J ]. Mol Cancer Res, 2011,9 (10) :1269 - 84.
  • 7Hu T, Guo H, Wang W, et al. Loss of p57 expression and RhoA overexpression associated with poor survival of patients with hepa- tocellular carcinoma[J]. Oncol Rep, 2013,30(4) :1707 - 14.
  • 8Black J D, English D P, Roque D M, Santin A D. Targeted thera- py in uterine serous carcinoma: an aggressive variant of endometri- al cancer [ J ]. Womens Health ( Lond Engl), 2014,10 ( 1 ):45 - 57.
  • 9Cooley A, Zelivianski S, Jeruss J S. Impact of Cyclin E overex- pression on Smad3 activity in breast cancer cell lines [ J ]. Cell Cy- cle, 2010,9(24) :4900 -7.
  • 10Borges K S, Arboleda V A, Vilain E. Mutations in the PCNA- binding site of CDKN1C inhibit cell proliferation by impairing the entry into S phase[J]. Cell Div, 2015,10:2.

引证文献1

二级引证文献5

临床肿瘤学杂志
2012年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部