31例托拉塞米注射剂治疗急性左心衰竭的临床分析

Clinical analysis of 31 cases of Torasemide injection in the treatment of acute left ventricular failure

目的:探讨托拉塞米对急性左心衰竭的疗效和安全性。方法:将62例急性左心衰竭患者随机分为托拉塞米组(31例)和呋塞米组(31例),托拉塞米组应用托拉塞米20～80 mg/d,呋塞米组应用呋塞米20～100 mg/d,余治疗相同。观察两组的疗效、肾功能、电解质、尿酸、血糖、甘油三脂(TG)和不良反应。结果:①托拉塞米组心力衰竭缓解率为93.55%;呋塞米组心力衰竭缓解率为54.84%,组间差异有统计学意义(P<0.05);②两组间比较总不良反应发生率(P>0.05)差异无统计学意义,但两组低钾比较(P<0.05)差异有统计学意义。结论:托拉塞米治疗急性左心衰竭疗效显著,安全性好。

Objective ： To explore the efficacy and safety of Torasemide in the treatment of acute left heart failure. Methods ：62 patients with acute left heart failure were randomly divided into Torasemide group （31 cases） and Furosemide group （31 cases）. To- rasemide 20 - 80mg/d was applied to Torasemide group and Furosemide group received Furosemide 20 - 100mg/d. Then we observed the curative effect, kidney function, electrolyte, uric acid, blood glucose triglycerides （TG） and adverse reaction of the two groups. Results： （1） Torasemide group~ remission rate of heart failure was 93.55% ; while the Furosemide groupg remission rate of heart failure was 54.84%. The difference between groups was statistically significant （ P 〈 0.05 ）. （2） Comparison of difference in the total adverse reaction rate （ P 〉 0.05 ） between the two groups had no statistical significance, but the comparison （ P 〈 0.05 ） of difference in low potassium was statistically significant. Conclusions： Torasemide is more effective and safe in the treatment of acute left heart failure.