氯沙坦治疗高血压病的研究

EFFECT OF LOSARTAN ON ESSENTIAL HYPERTENTION

目的 :观察氯沙坦对高血压病患者的临床疗效及安全性。方法 :30例患者分为 3组 :1组为服用原有降压药物产生不良反应需要停药 ,换用氯沙坦者 14人 ;2组为原有降压药物效果不佳 (BP≥ 140 /90mmHg)直接加用氯沙坦者 12人 ;3组为原发高血压未用降压药物者 4人。 3组均以氯沙坦 5 0mg ,qd为起始剂量 ,第 4周平均血压≥ 140 /90mmHg者加用双氢克尿噻 12 5mg ,qd。结果 :1组换用氯沙坦后全部不良反应消失 ,耐受良好且降压效果与原有药物相似或更好 ;2组 6周时血压由 (15 8 3± 15 5 ) /(10 1 0± 5 7)mmHg降至 (134 5± 12 0 ) /(83 0±6 8)mmHg,5 8 3%的患者血压降至正常 ;3组 6周时血压由 (147 4± 8 2 ) /(10 0 3± 6 8)mmHg降至(134 2± 5 0 ) /(85 0± 5 8)mmHg ,全部降至正常。结论 :氯沙坦是一种有效的。

OBJECTIVE: To evaluate the antihypertensive effect and safety of losartan METHODS: 30 patients with essential hypertention in three groups: 1 Use losartan instead of other antihypertensive drugs because of side effect in 14 patients; 2 Compined losartan in BP≥140/90 mmHg of having previous antihypertensive drugs in 12 patients; 3 Use losartan for new patients in 4 patients The three group were given 50 mg, qd After 4 weeks,if the average BP≥140/90 mmHg, combined DHCT 12 5 mg qd RESULTS: The previous side effect in group 1 was reduced The patients were well tolerated and have the same or better curtive effect The blood pressure reduced from (158 3±15 5)/(101 0±5 7) mmHg to (134 5±12 0)/(83 0±6 8) mmHg and (147 4±8 2)/(100 3±6 8) mmHg to (134 2±5 0)/(85 0±5 8) mmHg in group 2 and 3 respectively CONCLUSION: Losartan is a good effective and well tolerated agent for treatment of mild to moderate essential hypertention