国产咪唑安定在全麻手术中的应用

APPLICATION OF CHINESE MIDAZOLAM FOR OPERATIONS IN GENERAL ANESTHESIA

目的 :观察国产咪唑安定用作术前药和麻醉药的临床效果及对呼吸循环的影响。方法 :随机选择胸腹部手术患者 40例 ,术前用药为国产咪唑安定 0 0 7～ 0 1mg/kg ,术前 30min肌注 ;麻醉诱导用咪唑安定 0 2 0～0 30mg/kg、芬太尼 4μg/kg和琥珀胆碱 1～ 2mg/kg静注后气管内插管 ,人工通气 ,安氟醚维持麻醉。 结果 :肌注后患者安静者 30例 ,嗜睡者 10例 ;静注后对呼吸、循环无明显影响 (P >0 .0 5 ) ,意识消失时间为 (40 5± 2 1 6 )s。用药后无不良反应。结论 :国产咪唑安定镇静、催眠和麻醉诱导安全效果良好 。

OBJECTIVE: To study the efficacy and hemodynamic responses of chinese midazolam for premeditation and induction of anesthesia METHODS: The study was conducted in 40 patients Chinese midazolam 0 07～0 10 mg/kg im was used for premedication, and 0 20～0 30 mg/kg and fentanyl4 μg/kg iv were used for induction of anesthesia, hemodynamic, respiratory and hepatic function parameter.RESULTS: After intramuscularly and intravenously adminis tered chinese midazolam, sedation, hypnoses and time to loss of conscious ness were 30 and 10 patients and (40 5±21 6)s respectively Hemodynamic and respiratory function didnt obviously changes ( P >0 05), there were no statistical significance changes in MAP, HR, RPP, PRR, SpO 2, ETCO 2 and ALT, AST, TBil, BUN, Cr, BRT ( P > 0 05 ) CONCLUSION: Chinese midazolam is a safe and effective anesthetic for premeditation and induction of anesthesia, it may provide rapid, hemodynamically stable sedation and induction of anesthesia in patient for surgery