泮托拉唑与奥美拉唑治疗十二指肠溃疡的疗效比较

A COMPARISON OF PANTOPRAZOLE VS OMEPRAZOLE IN TREATMENT OF DUODENAL ULCERS

目的 :了解泮托拉唑治疗十二指肠溃疡的疗效和安全性。方法 :82例十二指肠溃疡患者随机分为 2组 ,各 41例。分别服泮托拉唑 40mg和奥美拉唑 2 0mg ,qd ,疗效均为 2周。 结果 :两组溃疡愈合率分别为 75 6 %和 6 8 3% ,总有效率分别为 97 6 %与 10 0 % ,两组间无显著性差异 (P >0 0 5 ) ;两组腹痛消失时间分别为 (3 1±1 5 )和 (3 2± 1 6 )d ,无显著差别 (P >0 0 5 )。结论 :2周常规剂量 。

OBJECTIVE: To compare the effect and safety of pantoprazole and omeprazole in the treatment of duodenal ulcers METHODS: Patients with endoscopically confirmed active duodenal ulcers were randomized assigned to received pantoprazole 40 mg,qd or omeprazole 20 mg/day for 2 weeks The ulcers healing were investigated with endoscopy after cessation of drugs The symptomatic relief was assessed before、during and after treatment RESULTS: After 2 weeks, duodenal ulcers healing was found in 75 6% of the pantoprazole group (31/41) and in 68 3% of omeprazole group (28/41), there is no significant difference ( P >0 05) The pain relief was no significant difference between two group ( P >0 05) CONCLUSION: The duodenal ulcers healing at 2 weeks was similar between pantoprazole and omeprazole